Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0046 | 0.0859 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0859 | 0.0859 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0859 | 0.0859 |
Schistosoma mansoni | acetylcholinesterase | 0.0046 | 0.0859 | 0.0859 |
Onchocerca volvulus | 0.0046 | 0.0859 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0046 | 0.0859 | 0.0859 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0859 | 0.0859 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0046 | 0.0859 | 0.0859 |
Brugia malayi | Carboxylesterase family protein | 0.0046 | 0.0859 | 0.0859 |
Onchocerca volvulus | 0.0046 | 0.0859 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0274 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0046 | 0.0859 | 0.0859 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.581 | 0.581 |
Loa Loa (eye worm) | carboxylesterase | 0.0274 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0274 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0046 | 0.0859 | 0.0859 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0274 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0046 | 0.0859 | 0.5 |
Onchocerca volvulus | 0.0046 | 0.0859 | 0.5 | |
Onchocerca volvulus | 0.0046 | 0.0859 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0274 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0046 | 0.0859 | 0.0859 |
Brugia malayi | hypothetical protein | 0.0046 | 0.0859 | 0.0859 |
Echinococcus granulosus | carboxylesterase 5A | 0.0274 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0046 | 0.0859 | 0.0859 |
Brugia malayi | Carboxylesterase family protein | 0.0046 | 0.0859 | 0.0859 |
Echinococcus multilocularis | acetylcholinesterase | 0.0274 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0046 | 0.0859 | 0.5 |
Echinococcus multilocularis | geminin | 0.017 | 0.581 | 0.581 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0859 | 0.0859 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0046 | 0.0859 | 0.0859 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0046 | 0.0859 | 0.0859 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0046 | 0.0859 | 0.0859 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0046 | 0.0859 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.581 | 0.581 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0046 | 0.0859 | 0.0859 |
Brugia malayi | Carboxylesterase family protein | 0.0046 | 0.0859 | 0.0859 |
Onchocerca volvulus | 0.0046 | 0.0859 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0274 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0046 | 0.0859 | 0.0859 |
Schistosoma mansoni | gliotactin | 0.0046 | 0.0859 | 0.0859 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0859 | 0.0859 |
Echinococcus granulosus | neuroligin | 0.0046 | 0.0859 | 0.0859 |
Echinococcus granulosus | acetylcholinesterase | 0.0274 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0859 | 0.0859 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0046 | 0.0859 | 0.0859 |
Echinococcus multilocularis | neuroligin | 0.0046 | 0.0859 | 0.0859 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0046 | 0.0859 | 0.0859 |
Echinococcus granulosus | geminin | 0.017 | 0.581 | 0.581 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0859 | 0.0859 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0046 | 0.0859 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0046 | 0.0859 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0274 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0046 | 0.0859 | 0.0859 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.