Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 4D, cAMP-specific | Starlite/ChEMBL | References |
Homo sapiens | phosphodiesterase 4B, cAMP-specific | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0958 | 0.3375 | 0.3375 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.2453 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0958 | 0.3375 | 0.5 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.0223 | 0.012 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.2453 | 1 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0958 | 0.3375 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.2453 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.012 | 1 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0223 | 0.012 | 0.0357 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0958 | 0.3375 | 1 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0223 | 0.012 | 0.0357 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0811 | 0.2726 | 0.8075 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.2453 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0958 | 0.3375 | 0.5 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.2453 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0958 | 0.3375 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0958 | 0.3375 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.2453 | 1 | 1 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0223 | 0.012 | 0.0357 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.2453 | 1 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0958 | 0.3375 | 0.5 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0958 | 0.3375 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.082 | 0.2763 | 0.8185 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.2453 | 1 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0958 | 0.3375 | 1 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0223 | 0.012 | 0.0357 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.2453 | 1 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.2453 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.2453 | 1 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.2453 | 1 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.2453 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0958 | 0.3375 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.2453 | 1 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0549 | 0.1565 | 0.1565 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0958 | 0.3375 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 540 nM | Inhibition of human PDE4B1 incubated for 10 mins using cAMP and [3H]cAMP substrates | ChEMBL. | 19447034 |
IC50 (binding) | = 8000 nM | Inhibition of human PDE4D3 incubated for 10 mins using cAMP and [3H]cAMP substrates | ChEMBL. | 19447034 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.