Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0251 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.0853 | 0.0853 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0251 | 1 | 1 |
Onchocerca volvulus | 0.0251 | 1 | 0.5 | |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0251 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.0853 | 0.0853 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.0853 | 0.0853 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0251 | 1 | 1 |
Schistosoma mansoni | tyrosinase precursor | 0.0251 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.0853 | 0.5 |
Onchocerca volvulus | 0.0251 | 1 | 0.5 | |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.0853 | 0.0853 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.0853 | 0.0853 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.0853 | 0.0853 |
Onchocerca volvulus | 0.0251 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 1 | 1 |
Onchocerca volvulus | 0.0251 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0251 | 1 | 1 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0251 | 1 | 1 |
Schistosoma mansoni | tyrosinase precursor | 0.0251 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0251 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.0853 | 0.5 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0251 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.8356 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.