Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase C, alpha | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0666 | 1 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.0666 | 1 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0666 | 1 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0003 | 0.0003 |
Brugia malayi | Protein kinase c protein 2 | 0.0057 | 0.071 | 0.0706 |
Echinococcus multilocularis | protein kinase c iota type | 0.0018 | 0.0115 | 0.0111 |
Schistosoma mansoni | glycogen phosphorylase | 0.0666 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0666 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0666 | 1 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.0666 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0666 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0003 | 0.0003 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0019 | 0.0138 | 0.0134 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0666 | 1 | 1 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0049 | 0.0598 | 0.0595 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0288 | 0.4236 | 0.4234 |
Echinococcus granulosus | protein kinase c iota type | 0.0018 | 0.0115 | 0.0111 |
Echinococcus granulosus | protein kinase C gamma type | 0.0059 | 0.0752 | 0.0749 |
Entamoeba histolytica | glycogenphosphorylase, putative | 0.0288 | 0.4236 | 0.4234 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0572 | 0.0569 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0003 | 0.0003 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0067 | 0.0864 | 0.086 |
Echinococcus granulosus | glycogen phosphorylase | 0.0666 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0019 | 0.0138 | 0.0134 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0666 | 1 | 1 |
Brugia malayi | protein kinase C II. | 0.0019 | 0.0138 | 0.0134 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.001 | 0.0003 | 0.5 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0019 | 0.0138 | 0.0134 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0288 | 0.4236 | 0.4234 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0003 | 0.0003 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0067 | 0.0864 | 0.086 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0003 | 0.0003 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0666 | 1 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.0018 | 0.0115 | 0.0111 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0059 | 0.0752 | 0.0749 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0666 | 1 | 1 |
Toxoplasma gondii | AGC kinase | 0.001 | 0.0003 | 0.5 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0288 | 0.4236 | 0.5 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0019 | 0.0138 | 0.0134 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0288 | 0.4236 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0683 | 0.068 |
Schistosoma mansoni | glycogen phosphorylase | 0.0666 | 1 | 1 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0048 | 0.0572 | 0.0569 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0003 | 0.0003 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0048 | 0.0572 | 0.0569 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0003 | 0.0003 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0666 | 1 | 1 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0067 | 0.0864 | 0.086 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0048 | 0.0572 | 0.0569 |
Schistosoma mansoni | glycogen phosphorylase | 0.0288 | 0.4236 | 0.4234 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0003 | 0.0003 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0003 | 0.0003 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0067 | 0.0864 | 0.086 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0666 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.043 uM | Displacement of [3H]PDBu from human recombinant PKCalpha after 20 mins by liquid scintillation counting | ChEMBL. | 21596562 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.