Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0197 | 1 | 1 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0013 | 0.0013 | 0.0013 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0013 | 0.0013 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0013 | 0.0013 | 0.0013 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0013 | 0.0013 | 0.0013 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0013 | 0.0013 | 1 |
Leishmania major | pteridine reductase 1 | 0.0013 | 0.0013 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0013 | 0.0013 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0013 | 0.0013 | 0.0013 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0013 | 0.0013 | 1 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0013 | 0.0013 | 1 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0013 | 0.0013 | 0.5 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0013 | 0.0013 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0197 | 1 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0197 | 1 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0013 | 0.0013 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0013 | 0.0013 | 0.0013 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0013 | 0.0013 | 0.0013 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0013 | 0.0013 | 0.0013 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0013 | 0.0013 | 1 |
Mycobacterium ulcerans | 20-beta-hydroxysteroid dehydrogenase FabG3 | 0.0013 | 0.0013 | 0.0013 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0013 | 0.0013 | 0.0013 |
Leishmania major | oxidoreductase-like protein | 0.0013 | 0.0013 | 1 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0013 | 0.0013 | 0.0013 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0197 | 1 | 1 |
Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0013 | 0.0013 | 0.0013 |
Trichomonas vaginalis | hypothetical protein | 0.0197 | 1 | 0.5 |
Trypanosoma brucei | pteridine reductase 1 | 0.0013 | 0.0013 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0197 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0197 | 1 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0013 | 0.0013 | 0.0013 |
Schistosoma mansoni | dihydropteridine reductase | 0.0013 | 0.0013 | 0.5 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0013 | 0.0013 | 0.0013 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0013 | 0.0013 | 0.0013 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0013 | 0.0013 | 0.0013 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0013 | 0.0013 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0013 | 1 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0013 | 0.0013 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0013 | 0.0013 | 0.0013 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0013 | 0.0013 | 0.0013 |
Onchocerca volvulus | 0.0013 | 0.0013 | 0.5 | |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0013 | 0.0013 | 0.0013 |
Mycobacterium ulcerans | oxidoreductase | 0.0013 | 0.0013 | 0.0013 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0197 | 1 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0013 | 0.0013 | 0.0013 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0013 | 0.0013 | 0.0013 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0013 | 0.0013 | 0.0013 |
Onchocerca volvulus | 0.0013 | 0.0013 | 0.5 | |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0013 | 0.0013 | 0.0013 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0013 | 0.0013 | 0.0013 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0013 | 0.0013 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0013 | 0.0013 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP reductase | 0.0013 | 0.0013 | 0.0013 |
Mycobacterium ulcerans | 3-oxoacyl-ACP reductase | 0.0013 | 0.0013 | 0.0013 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0013 | 0.0013 | 1 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0013 | 0.0013 | 0.0013 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0013 | 0.0013 | 0.5 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0013 | 0.0013 | 0.0013 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0013 | 0.0013 | 0.0013 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0013 | 0.0013 | 1 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0013 | 0.0013 | 0.0013 |
Loa Loa (eye worm) | oxidoreductase | 0.0013 | 0.0013 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 10 uM | Growth inhibition of human HeLa cells after 72 hrs by MTT assay | ChEMBL. | 19428245 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 19428245 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.