Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.021 | 0.1702 | 0.5 |
Echinococcus multilocularis | glutamyl tRNA(Gln) amidotransferase subunit A | 0.0104 | 0.0348 | 0.0348 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0104 | 0.0348 | 0.0348 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.086 | 1 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.021 | 0.1702 | 1 |
Leishmania major | monoglyceride lipase, putative | 0.021 | 0.1702 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.021 | 0.1702 | 0.5 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.021 | 0.1702 | 0.1453 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.021 | 0.1702 | 0.5 |
Brugia malayi | Amidase family protein | 0.0104 | 0.0348 | 0.0348 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.021 | 0.1702 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.021 | 0.1702 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.021 | 0.1702 | 0.5 |
Schistosoma mansoni | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0104 | 0.0348 | 0.0348 |
Mycobacterium ulcerans | hypothetical protein | 0.021 | 0.1702 | 0.1426 |
Plasmodium vivax | PST-A protein | 0.021 | 0.1702 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.086 | 1 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0104 | 0.0348 | 0.0348 |
Plasmodium falciparum | lysophospholipase, putative | 0.021 | 0.1702 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.021 | 0.1702 | 1 |
Mycobacterium ulcerans | lysophospholipase | 0.021 | 0.1702 | 0.1426 |
Brugia malayi | putative amidase | 0.0104 | 0.0348 | 0.0348 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.021 | 0.1702 | 1 |
Brugia malayi | Amidase family protein | 0.0104 | 0.0348 | 0.0348 |
Loa Loa (eye worm) | amidase | 0.0104 | 0.0348 | 0.0348 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.021 | 0.1702 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.086 | 1 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0104 | 0.0348 | 0.0348 |
Loa Loa (eye worm) | amidase | 0.0104 | 0.0348 | 0.0348 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0104 | 0.0348 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.086 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.021 | 0.1702 | 0.5 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0104 | 0.0348 | 0.5 |
Echinococcus granulosus | glutamyl tRNAGln amidotransferase subunit A | 0.0104 | 0.0348 | 0.0348 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.021 | 0.1702 | 0.5 |
Plasmodium falciparum | esterase, putative | 0.021 | 0.1702 | 1 |
Mycobacterium tuberculosis | 4,9-DHSA hydrolase | 0.0834 | 0.967 | 1 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.021 | 0.1702 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.021 | 0.1702 | 0.5 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0104 | 0.0348 | 0.5 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.021 | 0.1702 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.021 | 0.1702 | 0.5 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.086 | 1 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.086 | 1 | 1 |
Schistosoma mansoni | amidase | 0.086 | 1 | 1 |
Mycobacterium ulcerans | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD | 0.0848 | 0.9843 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.5623 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.6535 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.