TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 698.677 | Formula: C35H38Cl2FN5O3S
H donors: 1 H acceptors: 4 LogP: 6.63 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: Clc1ccc(cc1F)C1(CCN2C3CCC2CC(C3)n2c(C)nc3c2cccc3)CCN(CC1)C(=O)c1ccc(c(c1)S(=O)(=O)N)Cl
InChi: 1S/C35H38Cl2FN5O3S/c1-22-40-31-4-2-3-5-32(31)43(22)27-20-25-8-9-26(21-27)42(25)17-14-35(24-7-11-28(36)30(38)19-24)12-15-41(16-13-35)34(44)23-6-10-29(37)33(18-23)47(39,45)46/h2-7,10-11,18-19,25-27H,8-9,12-17,20-21H2,1H3,(H2,39,45,46)
InChiKey: FDOKOHKREXFVQN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0052	0.073	0.346
Echinococcus multilocularis	aldo keto reductase	0.0032	0.027	0.0204
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0052	0.073	0.0924
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0262	0.5369	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0024	0.0105	0.0195
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0052	0.073	0.0924
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0106	0.1912	1
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0052	0.073	0.0667
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0032	0.027	0.0204
Echinococcus granulosus	fructose 16 bisphosphate aldolase	0.0093	0.163	0.1574
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0052	0.073	0.4478
Onchocerca volvulus		0.0032	0.027	0.0132
Loa Loa (eye worm)	tubulin beta-4 chain	0.0024	0.0105	0.0133
Trypanosoma brucei	aldo-keto reductase, putative	0.0032	0.027	0.0913
Trypanosoma cruzi	fructose-bisphosphate aldolase, glycosomal, putative	0.0093	0.163	0.8444
Onchocerca volvulus		0.0032	0.027	0.0132
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0052	0.073	0.0667
Trypanosoma cruzi	fructose-bisphosphate aldolase, glycosomal, putative	0.0093	0.163	0.8444
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.1912	0.3561
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0032	0.027	0.0204
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0052	0.073	0.0632
Echinococcus granulosus	lipoxygenase domain containing protein	0.0079	0.1314	0.1255
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0052	0.073	0.0632
Toxoplasma gondii	beta-tubulin, putative	0.0024	0.0105	0.0133
Onchocerca volvulus		0.0032	0.027	0.0132
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0052	0.073	0.4478
Loa Loa (eye worm)	BEN-1 protein	0.0024	0.0105	0.0133
Toxoplasma gondii	hypothetical protein	0.0053	0.0752	0.0952
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.1912	0.3561
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0262	0.5369	1
Brugia malayi	hypothetical protein	0.0079	0.1314	0.1823
Toxoplasma gondii	PHD-finger domain-containing protein	0.0028	0.0201	0.0255
Schistosoma mansoni	aldo-keto reductase	0.0032	0.027	0.0167
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0052	0.073	0.0924
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.1912	0.3561
Plasmodium falciparum	phosphodiesterase delta, putative	0.0052	0.073	0.4478
Trichomonas vaginalis	aldo-keto reductase, putative	0.0032	0.027	0.0502
Trichomonas vaginalis	aldo-keto reductase, putative	0.0032	0.027	0.0502
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0052	0.073	0.0924
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0072	0.1159	0.1099
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0052	0.073	0.0632
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0052	0.073	0.0924
Loa Loa (eye worm)	fructose-bisphosphate aldolase 2	0.0093	0.163	0.2064
Schistosoma mansoni	fructose 16-bisphosphate aldolase	0.0093	0.163	0.1542
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0262	0.5369	0.7933
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0376	0.79	0.7886
Brugia malayi	fructose-bisphosphate aldolase 2	0.0093	0.163	0.2299
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0052	0.073	0.0632
Echinococcus granulosus	Polycystic kidney disease protein	0.0079	0.1314	0.1255
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0052	0.073	0.0924
Echinococcus granulosus	aldo keto reductase	0.0032	0.027	0.0204
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0052	0.073	0.0924
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.0334	0.0232
Leishmania major	prostaglandin f synthase, putative	0.0032	0.027	0.0913
Giardia lamblia	hypothetical protein	0.0052	0.073	0.0802
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0052	0.073	0.136
Loa Loa (eye worm)	oxidoreductase	0.0032	0.027	0.0341
Onchocerca volvulus		0.0032	0.027	0.0132
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0752	0.1401
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0262	0.5369	1
Echinococcus granulosus	lipoxygenase domain containing protein	0.0079	0.1314	0.1255
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0032	0.027	0.0204
Entamoeba histolytica	aldose reductase, putative	0.0032	0.027	0.0313
Schistosoma mansoni	polycystin 1-related	0.0079	0.1314	0.1222
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0052	0.073	0.346
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.1912	0.3561
Echinococcus granulosus	beta tubulin	0.0024	0.0105	0.0038
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.0873	0.1105
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0052	0.073	0.0942
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0072	0.1159	0.2159
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0052	0.073	0.0924
Plasmodium vivax	fructose 1,6-bisphosphate aldolase, putative	0.0093	0.163	1
Schistosoma mansoni	lipoxygenase	0.047	1	1
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0052	0.073	0.4478
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0052	0.073	0.346
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0106	0.1912	0.3561
Plasmodium falciparum	phd finger protein, putative	0.0028	0.0201	0.1236
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0052	0.073	0.136
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0032	0.027	0.0204
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0262	0.5369	1
Loa Loa (eye worm)	oxidoreductase	0.0032	0.027	0.0341
Echinococcus multilocularis	aldo keto reductase	0.0032	0.027	0.0204
Toxoplasma gondii	fructose-1,6-bisphosphate aldolase	0.0093	0.163	0.2064
Loa Loa (eye worm)	tubulin beta chain	0.0024	0.0105	0.0133
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0052	0.073	0.346
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0376	0.79	0.7886
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.1912	0.3561
Schistosoma mansoni	aldo-keto reductase	0.0032	0.027	0.0167
Echinococcus granulosus	RUN	0.0079	0.1314	0.1255
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0052	0.073	0.0942
Echinococcus granulosus	peregrin	0.0028	0.0201	0.0135
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0052	0.073	0.0924
Onchocerca volvulus		0.0032	0.027	0.0132
Giardia lamblia	Aldose reductase	0.0032	0.027	0.0212
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0052	0.073	0.0632
Trichomonas vaginalis	tubulin alpha chain, putative	0.0024	0.0105	0.0195
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0072	0.1159	0.1589
Loa Loa (eye worm)	hypothetical protein	0.0376	0.79	1
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0052	0.073	0.4478
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0106	0.1912	0.3561
Plasmodium falciparum	tubulin beta chain	0.0024	0.0105	0.0643
Toxoplasma gondii	aldose reductase, putative	0.0032	0.027	0.0341
Echinococcus granulosus	Tubulin beta 2C chain	0.0024	0.0105	0.0038
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0106	0.1912	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0032	0.027	0.0502
Giardia lamblia	Aldose reductase	0.0032	0.027	0.0212
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0032	0.027	0.0204
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0106	0.1912	0.3561
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0106	0.1912	0.3561
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0032	0.027	0.0204
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0032	0.027	0.0502
Echinococcus multilocularis	lysine specific demethylase 5A	0.0034	0.0334	0.0269
Schistosoma mansoni	hypothetical protein	0.0028	0.0201	0.0098
Plasmodium vivax	phosphodiesterase gamma, putative	0.0052	0.073	0.4478
Leishmania major	hypothetical protein, conserved	0.0052	0.073	0.346
Trichomonas vaginalis	tubulin gamma chain, putative	0.0024	0.0105	0.0195
Schistosoma mansoni	pol-related	0.0032	0.027	0.0167
Brugia malayi	fructose-bisphosphate aldolase 1	0.0093	0.163	0.2299
Echinococcus multilocularis	jumonji domain containing protein	0.004	0.0448	0.0384
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0086	0.1482	0.2761
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0024	0.0105	0.0195
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0106	0.1912	0.1857
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0086	0.1482	0.2761
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0052	0.073	0.4478
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0106	0.1912	0.3561
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0052	0.073	0.0632
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0106	0.1912	0.3561
Loa Loa (eye worm)	tubulin beta-1 chain	0.0024	0.0105	0.0133
Plasmodium vivax	hypothetical protein, conserved	0.0028	0.0201	0.1236
Schistosoma mansoni	lipoxygenase	0.0329	0.6862	0.6828
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.1912	0.3561
Brugia malayi	jmjC domain containing protein	0.0093	0.1636	0.2308
Onchocerca volvulus		0.0079	0.1314	0.2154
Echinococcus multilocularis	fructose bisphosphate aldolase class I	0.0093	0.163	0.1574
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0052	0.073	0.136
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0072	0.1159	0.2159
Trichomonas vaginalis	aldo-keto reductase, putative	0.0032	0.027	0.0502
Loa Loa (eye worm)	oxidoreductase	0.0032	0.027	0.0341
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0323	0.6741	0.6718
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0652	0.0825
Echinococcus multilocularis	Tubulin beta 2C chain	0.0024	0.0105	0.0038
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0052	0.073	0.0632
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0052	0.073	0.346
Trichomonas vaginalis	aldo/keto reductase, putative	0.0032	0.027	0.0502
Toxoplasma gondii	PHD-finger domain-containing protein	0.0028	0.0201	0.0255
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0376	0.79	0.7886
Echinococcus multilocularis	beta tubulin	0.0024	0.0105	0.0038
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.0334	0.0232
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0093	0.1636	0.158
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0052	0.073	0.0942
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0052	0.073	0.346
Echinococcus granulosus	fructose bisphosphate aldolase class I	0.0093	0.163	0.1574
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.047	1	1
Echinococcus granulosus	tubulin subunit beta	0.0024	0.0105	0.0038
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.1912	0.3561
Echinococcus multilocularis	aldo keto reductase	0.0032	0.027	0.0204
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0032	0.027	0.0204
Trichomonas vaginalis	aldo-keto reductase, putative	0.0032	0.027	0.0502
Plasmodium falciparum	fructose-bisphosphate aldolase	0.0093	0.163	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.1912	0.3561
Echinococcus granulosus	hypothetical protein	0.0032	0.027	0.0204
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0052	0.073	0.4478
Echinococcus multilocularis	peregrin	0.0028	0.0201	0.0135
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0024	0.0105	0.0195
Toxoplasma gondii	beta tubulin	0.0024	0.0105	0.0133
Schistosoma mansoni	jumonji domain containing protein	0.0074	0.1212	0.1119
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0752	0.1401
Echinococcus multilocularis	Polycystic kidney disease protein	0.0079	0.1314	0.1255
Trypanosoma cruzi	hypothetical protein, conserved	0.0052	0.073	0.346
Trichomonas vaginalis	aldo-keto reductase, putative	0.0032	0.027	0.0502
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0323	0.6741	0.8533
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.1912	0.3561
Trypanosoma cruzi	aldo-keto reductase	0.0032	0.027	0.0913
Schistosoma mansoni	loxhd1	0.0079	0.1314	0.1222
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0262	0.5369	1
Onchocerca volvulus		0.0079	0.1314	0.2154
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1314	0.1664
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.1912	0.3561
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0106	0.1912	0.3561
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0052	0.073	0.0924
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0032	0.027	0.0913
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0052	0.073	0.136
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0052	0.073	0.136
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0106	0.1912	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0032	0.027	0.0502
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0262	0.5369	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0032	0.027	0.0502
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0262	0.5369	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0032	0.027	0.0502
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0032	0.027	0.0248
Toxoplasma gondii	fructose-bisphosphate aldolase, putative	0.0093	0.163	0.2064
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0262	0.5369	0.6796
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0052	0.073	0.136
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0032	0.027	0.0204
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0052	0.073	0.0924
Trypanosoma cruzi	fructose-bisphosphate aldolase, glycosomal, putative	0.0093	0.163	0.8444
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0052	0.073	0.4478
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0052	0.073	0.0667
Toxoplasma gondii	fructose-1,6-bisphosphate aldolase	0.0093	0.163	0.2064
Loa Loa (eye worm)	PDE1B protein	0.0052	0.073	0.0924
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0032	0.027	0.0204
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0052	0.073	0.136
Echinococcus granulosus	lysine specific demethylase 5A	0.0034	0.0334	0.0269
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0032	0.027	0.0204
Loa Loa (eye worm)	fructose-bisphosphate aldolase 1	0.0093	0.163	0.2064
Echinococcus multilocularis	Tubulin beta 2C chain	0.0024	0.0105	0.0038
Echinococcus multilocularis	tubulin beta 1 chain	0.0024	0.0105	0.0038
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0052	0.073	0.0924
Leishmania major	hypothetical protein, conserved	0.0052	0.073	0.346
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0106	0.1912	0.1826
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0106	0.1912	0.1857
Loa Loa (eye worm)	oxidoreductase	0.0032	0.027	0.0341
Trichomonas vaginalis	conserved hypothetical protein	0.0052	0.073	0.136
Loa Loa (eye worm)	hypothetical protein	0.0052	0.073	0.0924
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0106	0.1912	0.3561
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.1912	0.3561
Trypanosoma cruzi	aldo/keto reductase, putative	0.0032	0.027	0.0913
Echinococcus granulosus	PHD finger protein rhinoceros	0.0028	0.0201	0.0135
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0052	0.073	0.0667
Entamoeba histolytica	aldose reductase, putative	0.0032	0.027	0.0313
Echinococcus granulosus	Tubulin beta 2C chain	0.0024	0.0105	0.0038
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0024	0.0105	0.0038
Plasmodium falciparum	LCCL domain-containing protein	0.0079	0.1314	0.8061
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0106	0.1912	0.3561
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0106	0.1912	0.3561
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0376	0.79	0.7878
Echinococcus granulosus	jumonji domain containing protein	0.004	0.0448	0.0384
Brugia malayi	jmjC domain containing protein	0.0034	0.0334	0.0346
Echinococcus multilocularis	Tubulin beta 2C chain	0.0024	0.0105	0.0038
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0032	0.027	1
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0376	0.79	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0024	0.0105	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0752	0.1401
Echinococcus granulosus	tubulin beta 1 chain	0.0024	0.0105	0.0038
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0376	0.79	0.7886
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1159	0.1467
Trichomonas vaginalis	aldo-keto reductase, putative	0.0032	0.027	0.0502
Echinococcus granulosus	aldo keto reductase	0.0032	0.027	0.0204
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0106	0.1912	0.3561
Plasmodium vivax	tubulin beta chain, putative	0.0024	0.0105	0.0643
Echinococcus granulosus	aldo keto reductase	0.0032	0.027	0.0204
Loa Loa (eye worm)	beta-tubulin	0.0024	0.0105	0.0133
Loa Loa (eye worm)	tubulin beta-2A chain	0.0024	0.0105	0.0133
Echinococcus multilocularis	beta tubulin	0.0024	0.0105	0.0038
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0032	0.027	0.0204
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0052	0.073	0.0632
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0052	0.073	0.136
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0262	0.5369	1
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0052	0.073	0.4478
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0052	0.073	0.136
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0052	0.073	0.346
Trypanosoma brucei	hypothetical protein, conserved	0.0052	0.073	0.346
Brugia malayi	Doublecortin family protein	0.0079	0.1314	0.1823
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0032	0.027	0.0204
Loa Loa (eye worm)	doublecortin family protein	0.0079	0.1314	0.1664
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0262	0.5369	1
Trypanosoma cruzi	fructose-bisphosphate aldolase, glycosomal, putative	0.0093	0.163	0.8444
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0262	0.5369	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0032	0.027	0.0204
Schistosoma mansoni	rab6-interacting	0.0079	0.1314	0.1222
Echinococcus granulosus	tubulin beta 4A class IVa	0.0024	0.0105	0.0038
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0106	0.1912	1
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0032	0.027	0.0913
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0323	0.6741	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0032	0.027	0.0502
Trichomonas vaginalis	conserved hypothetical protein	0.0052	0.073	0.136
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0032	0.027	0.0204
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0052	0.073	0.0667
Loa Loa (eye worm)	PHD-finger family protein	0.0028	0.0201	0.0255
Trypanosoma cruzi	hypothetical protein, conserved	0.0052	0.073	0.346
Echinococcus granulosus	beta tubulin	0.0024	0.0105	0.0038
Schistosoma mansoni	rab6-interacting	0.0079	0.1314	0.1222
Mycobacterium ulcerans	oxidoreductase	0.0032	0.027	0.0502
Loa Loa (eye worm)	hypothetical protein	0.0032	0.027	0.0341
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0376	0.79	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0024	0.0105	0.0038
Echinococcus granulosus	fructose 16 bisphosphate aldolase	0.0093	0.163	0.1574
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0052	0.073	0.0924
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0052	0.073	0.0667
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0052	0.073	0.0942
Loa Loa (eye worm)	oxidoreductase	0.0032	0.027	0.0341
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0106	0.1912	0.3561
Onchocerca volvulus		0.0262	0.5369	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0024	0.0105	0.0038
Trypanosoma cruzi	hypothetical protein, conserved	0.0052	0.073	0.346
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0052	0.073	0.346
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0052	0.073	0.0667
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0032	0.027	0.0502
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0052	0.073	0.0667
Echinococcus granulosus	Tubulin beta 2C chain	0.0024	0.0105	0.0038
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0072	0.1159	0.1099
Trypanosoma cruzi	hypothetical protein, conserved	0.0052	0.073	0.346
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0086	0.1482	0.7625
Giardia lamblia	PHD finger protein 15	0.0028	0.0201	0.0124
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0106	0.1912	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0079	0.1314	0.1255
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0106	0.1912	0.3561
Loa Loa (eye worm)	hypothetical protein	0.0052	0.073	0.0924
Echinococcus multilocularis	tubulin subunit beta	0.0024	0.0105	0.0038
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0028	0.0201	0.0098
Trypanosoma cruzi	hypothetical protein, conserved	0.0052	0.073	0.346
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.1912	0.3561
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0032	0.027	0.0204
Brugia malayi	PHD-finger family protein	0.0028	0.0201	0.0146
Leishmania major	aldo-keto reductase-like protein	0.0032	0.027	0.0913
Plasmodium vivax	multidomain scavenger receptor, putative	0.0079	0.1314	0.8061
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0052	0.073	0.346
Leishmania major	fructose-1,6-bisphosphate aldolase	0.0093	0.163	0.8444
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0052	0.073	0.0924
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0032	0.027	0.0204
Trichomonas vaginalis	aldo-keto reductase, putative	0.0032	0.027	0.0502
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0032	0.027	0.0248
Entamoeba histolytica	aldose reductase, putative	0.0032	0.027	0.0313
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.1912	0.3561
Echinococcus granulosus	fructose 16 bisphosphate aldolase	0.0093	0.163	0.1574
Trypanosoma brucei	fructose-bisphosphate aldolase, glycosomal, putative	0.0093	0.163	0.8444
Onchocerca volvulus		0.0032	0.027	0.0132
Brugia malayi	Bromodomain containing protein	0.0028	0.0201	0.0146
Echinococcus granulosus	Tubulin beta 2C chain	0.0024	0.0105	0.0038
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0052	0.073	0.0924
Brugia malayi	hypothetical protein	0.0079	0.1314	0.1823
Loa Loa (eye worm)	jmjC domain-containing protein	0.0034	0.0334	0.0423
Echinococcus multilocularis	RUN	0.0079	0.1314	0.1255
Trichomonas vaginalis	aldo-keto reductase, putative	0.0032	0.027	0.0502
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0079	0.1314	0.1255
Echinococcus multilocularis	fructose 1,6 bisphosphate aldolase	0.0093	0.163	0.1574
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.1912	0.3561
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0072	0.1159	0.1589
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0262	0.5369	0.6753
Echinococcus multilocularis	fructose 1,6 bisphosphate aldolase	0.0093	0.163	0.1574
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0072	0.1159	0.1066
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0032	0.027	0.0248
Toxoplasma gondii	beta-1 tubulin, putative	0.0024	0.0105	0.0133
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0106	0.1912	0.3561
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0106	0.1912	0.3561
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0323	0.6741	0.6718
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0032	0.027	0.0204
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0093	0.1636	0.158
Echinococcus multilocularis	fructose 1,6 bisphosphate aldolase	0.0093	0.163	0.1574
Trichomonas vaginalis	tubulin, putative	0.0024	0.0105	0.0195
Schistosoma mansoni	fructose 16-bisphosphate aldolase	0.0093	0.163	0.1542
Trypanosoma cruzi	hypothetical protein, conserved	0.0052	0.073	0.346
Loa Loa (eye worm)	BEN-1 protein	0.0024	0.0105	0.0133
Trypanosoma brucei	prostaglandin f synthase	0.0032	0.027	0.0913
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0052	0.073	0.0924
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0201	0.0255
Echinococcus multilocularis	aldo keto reductase	0.0032	0.027	0.0204
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0032	0.027	0.0248
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0052	0.073	0.0924
Giardia lamblia	Hypothetical protein	0.0052	0.073	0.0802
Schistosoma mansoni	hypothetical protein	0.0079	0.1314	0.1222
Trichomonas vaginalis	aldo/keto reductase, putative	0.0032	0.027	0.0502
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0072	0.1159	0.2159
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1314	0.1664
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0032	0.027	0.0204
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0028	0.0201	0.0135
Trichomonas vaginalis	aldo/keto reductase, putative	0.0032	0.027	0.0502
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0032	0.027	0.0204
Mycobacterium tuberculosis	Probable oxidoreductase	0.0032	0.027	0.0502
Mycobacterium leprae	Conserved hypothetical protein	0.0022	0.0067	0.2495
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0052	0.073	0.346
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0032	0.027	0.0204
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0052	0.073	0.136
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0052	0.073	0.0924

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1784497

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1522215