Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.005 | 0.0292 | 0.0292 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.005 | 0.0292 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0829 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0292 | 0.0292 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.005 | 0.0292 | 0.0292 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.005 | 0.0292 | 1 |
Brugia malayi | nuclear hormone receptor | 0.005 | 0.0292 | 0.0292 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.005 | 0.0292 | 0.0292 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.005 | 0.0292 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.005 | 0.0292 | 0.0292 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.005 | 0.0292 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.005 | 0.0292 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0292 | 0.0292 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0292 | 0.0292 |
Leishmania major | fatty-acid desaturase, putative | 0.0829 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.005 | 0.0292 | 0.0292 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.005 | 0.0292 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0292 | 0.0292 |
Onchocerca volvulus | 0.0829 | 1 | 1 | |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.005 | 0.0292 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.005 | 0.0292 | 0.0292 |
Schistosoma mansoni | nuclear hormone receptor | 0.005 | 0.0292 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.005 | 0.0292 | 1 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0829 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.005 | 0.0292 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.005 | 0.0292 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.005 | 0.0292 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.005 | 0.0292 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.005 | 0.0292 | 0.0292 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.005 | 0.0292 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.005 | 0.0292 | 0.0292 |
Onchocerca volvulus | 0.0829 | 1 | 1 | |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0829 | 1 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.005 | 0.0292 | 0.0292 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0829 | 1 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.005 | 0.0292 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0292 | 0.0292 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.005 | 0.0292 | 0.0292 |
Leishmania major | stearic acid desaturase, putative | 0.0829 | 1 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.005 | 0.0292 | 0.0292 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.005 | 0.0292 | 0.0292 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.005 | 0.0292 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.005 | 0.0292 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.005 | 0.0292 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.005 | 0.0292 | 0.0292 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.005 | 0.0292 | 0.0292 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.005 | 0.0292 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.005 | 0.0292 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.005 | 0.0292 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.005 | 0.0292 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.005 | 0.0292 | 0.0292 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.005 | 0.0292 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.005 | 0.0292 | 0.0292 |
Brugia malayi | steroid hormone receptor | 0.005 | 0.0292 | 0.0292 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.005 | 0.0292 | 0.0292 |
Echinococcus granulosus | FTZ F1 alpha | 0.005 | 0.0292 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.005 | 0.0292 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0829 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.005 | 0.0292 | 0.0292 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.005 | 0.0292 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0292 | 0.0292 |
Brugia malayi | ecdysteroid receptor | 0.005 | 0.0292 | 0.0292 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.005 | 0.0292 | 0.0292 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.005 | 0.0292 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.005 | 0.0292 | 0.0292 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.005 | 0.0292 | 0.0292 |
Brugia malayi | nuclear receptor NHR-88 | 0.005 | 0.0292 | 0.0292 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.005 | 0.0292 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0292 | 0.0292 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0829 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.005 | 0.0292 | 0.0292 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0829 | 1 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.005 | 0.0292 | 0.0292 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0292 | 0.0292 |
Schistosoma mansoni | coup transcription factor | 0.005 | 0.0292 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.005 | 0.0292 | 0.0292 |
Schistosoma mansoni | thyroid hormone receptor | 0.005 | 0.0292 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.005 | 0.0292 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.