Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0015 | 0.1236 | 0.0233 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0015 | 0.1236 | 0.1236 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0015 | 0.1236 | 0.1236 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0015 | 0.1236 | 0.1236 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0015 | 0.1236 | 0.0233 |
Schistosoma mansoni | lamin | 0.0028 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0015 | 0.1236 | 0.0233 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0015 | 0.1236 | 0.0233 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0015 | 0.1236 | 0.0233 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0015 | 0.1236 | 0.1236 |
Schistosoma mansoni | lamin | 0.0028 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0015 | 0.1236 | 0.1236 |
Brugia malayi | steroid hormone receptor | 0.0015 | 0.1236 | 0.0233 |
Brugia malayi | ecdysteroid receptor | 0.0015 | 0.1236 | 0.0233 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0015 | 0.1236 | 0.0233 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0015 | 0.1236 | 0.1236 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1236 | 0.1236 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0015 | 0.1236 | 0.1236 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0015 | 0.1236 | 0.1236 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1236 | 0.1236 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.9646 | 0.9646 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0015 | 0.1236 | 0.1236 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0015 | 0.1236 | 0.1236 |
Brugia malayi | nuclear hormone receptor | 0.0015 | 0.1236 | 0.0233 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0015 | 0.1236 | 0.1236 |
Echinococcus multilocularis | lamin | 0.0028 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0015 | 0.1236 | 0.0233 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0015 | 0.1236 | 0.0233 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0015 | 0.1236 | 0.0233 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0015 | 0.1236 | 0.1236 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0015 | 0.1236 | 0.1236 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1236 | 0.1236 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0015 | 0.1236 | 0.1236 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0015 | 0.1236 | 0.1236 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0015 | 0.1236 | 0.1236 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1236 | 0.1236 |
Onchocerca volvulus | 0.0028 | 1 | 1 | |
Onchocerca volvulus | 0.0028 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1236 | 0.1236 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0015 | 0.1236 | 0.1236 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.1026 | 0.1026 |
Echinococcus multilocularis | musashi | 0.0028 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0015 | 0.1236 | 0.0233 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0015 | 0.1236 | 0.0233 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0015 | 0.1236 | 0.1236 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0015 | 0.1236 | 0.0233 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0015 | 0.1236 | 0.1236 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0015 | 0.1236 | 0.1236 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0015 | 0.1236 | 0.1236 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0015 | 0.1236 | 0.1236 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0015 | 0.1236 | 0.1236 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1236 | 0.1236 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0015 | 0.1236 | 0.1236 |
Echinococcus granulosus | lamin | 0.0028 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0015 | 0.1236 | 0.1236 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0015 | 0.1236 | 0.0233 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0015 | 0.1236 | 0.0233 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0015 | 0.1236 | 0.1236 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0015 | 0.1236 | 0.0233 |
Brugia malayi | nuclear receptor NHR-88 | 0.0015 | 0.1236 | 0.0233 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1236 | 0.1236 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0015 | 0.1236 | 0.0233 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1236 | 0.1236 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | mg kg-1 | Analgesic activity after peroral administration using PQW test; ND is No Data | ChEMBL. | 6600791 |
ED50 (functional) | mg kg-1 | Analgesic activity for subcutaneous administration using tail flick test; ND is no data | ChEMBL. | 6600791 |
ED50 (functional) | mg kg-1 | Analgesic activity after peroral administration using tail flick test; ND is no data | ChEMBL. | 6600791 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.