Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 10 | Starlite/ChEMBL | References |
Homo sapiens | mitogen-activated protein kinase 8 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | c-Jun N-terminal kinases | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Brugia malayi | Stress-activated protein kinase jnk-1 | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Schistosoma japonicum | IPR000164,Histone H3;IPR009072,Histone-fold,domain-containing | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Schistosoma japonicum | ko:K04440 c-Jun N-terminal kinase, putative | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | ryanodine receptor | 0.0181 | 0.2448 | 0.2448 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0148 | 0.1788 | 0.1788 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0392 | 0.6688 | 0.3434 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0392 | 0.6688 | 0.3434 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0174 | 0.2321 | 0.5 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0174 | 0.2321 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0306 | 0.4956 | 0.4956 |
Leishmania major | hypothetical protein, conserved | 0.0119 | 0.1199 | 0.5 |
Echinococcus granulosus | c-Jun N-terminal kinases | 0.0557 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0666 | 0.0666 |
Schistosoma mansoni | ryanodine receptor related | 0.0484 | 0.8538 | 0.8538 |
Schistosoma mansoni | hypothetical protein | 0.0119 | 0.1214 | 0.1214 |
Brugia malayi | Ryanodine Receptor TM 4-6 family protein | 0.0484 | 0.8538 | 0.792 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0589 | 0.0589 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0557 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | 0.0557 | 1 | 1 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | 0.0557 | 1 | 1 |
Loa Loa (eye worm) | ryanodine receptor | 0.0114 | 0.111 | 0.111 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.13 uM | Inhibition of JNK3 by TR-FRET assay | ChEMBL. | 21570836 |
IC50 (binding) | = 18.1 uM | Inhibition of JNK2 by TR-FRET assay | ChEMBL. | 21570836 |
IC50 (binding) | > 50 uM | Inhibition of JNK1 by TR-FRET assay | ChEMBL. | 21570836 |
Stability (ADMET) | = 0 % | Oxidative metabolic stability in mouse liver microsomes assessed as compound remaining after 30 mins | ChEMBL. | 21570836 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.