Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | ADAM metallopeptidase with thrombospondin type 1 motif, 4 | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 14 (membrane-inserted) | Starlite/ChEMBL | References |
Homo sapiens | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 13 (collagenase 3) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 13 (collagenase 3) | 471 aa | 448 aa | 34.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.0691 | 0.3463 |
Brugia malayi | Kinesin motor domain containing protein | 0.0206 | 0.0714 | 0.3596 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0219 | 0.0798 | 0.4097 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0206 | 0.0714 | 0.5 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0206 | 0.0714 | 0.3596 |
Entamoeba histolytica | kinesin, putative | 0.0206 | 0.0714 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0257 | 0.1055 | 0.6186 |
Loa Loa (eye worm) | matrixin family protein | 0.0367 | 0.1796 | 1 |
Schistosoma mansoni | hypothetical protein | 0.138 | 0.8614 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.0432 | 0.0501 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 0.0798 | 0.4097 |
Onchocerca volvulus | 0.0164 | 0.0432 | 0.2123 | |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0141 | 0.0276 | 0.5 |
Brugia malayi | Hemopexin family protein | 0.0164 | 0.0432 | 0.1927 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0141 | 0.0276 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0367 | 0.1796 | 1 |
Schistosoma mansoni | kinesin eg-5 | 0.0206 | 0.0714 | 0.0829 |
Echinococcus multilocularis | kinesin family 1 | 0.1587 | 1 | 1 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0203 | 0.0691 | 0.0802 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0141 | 0.0276 | 0.1005 |
Plasmodium vivax | kinesin-5 | 0.0206 | 0.0714 | 0.5 |
Giardia lamblia | Kinesin-5 | 0.0206 | 0.0714 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0276 | 0.1005 |
Loa Loa (eye worm) | matrixin family protein | 0.0257 | 0.1055 | 0.5616 |
Mycobacterium ulcerans | hydrolase | 0.0141 | 0.0276 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0344 | 0.164 | 1 |
Plasmodium falciparum | kinesin-5 | 0.0206 | 0.0714 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 51 nM | Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assay | ChEMBL. | 21536437 |
IC50 (binding) | = 1500 nM | Inhibition of ADAMTS-5 assessed as substrate cleavage after 16 hrs by fluorescence assay | ChEMBL. | 21536437 |
IC50 (binding) | > 10000 nM | Inhibition of recombinant human MMP-13 assessed as substrate cleavage after 20 hrs by fluorescence assay | ChEMBL. | 21536437 |
IC50 (binding) | > 10000 nM | Inhibition of recombinant human MMP-14 assessed as substrate cleavage after 20 hrs by fluorescence assay | ChEMBL. | 21536437 |
IC50 (binding) | > 10000 nM | Inhibition of recombinant human MMP-2 assessed as substrate cleavage after 20 hrs by fluorescence assay | ChEMBL. | 21536437 |
IC50 (binding) | > 10000 nM | Inhibition of recombinant human MMP-9 assessed as substrate cleavage after 20 hrs by fluorescence assay | ChEMBL. | 21536437 |
IC50 (binding) | > 10 uM | Inhibition of recombinant human MMP-1 assessed as substrate cleavage after 20 hrs by fluorescence assay | ChEMBL. | 21536437 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.