Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | References |
Homo sapiens | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 13 (collagenase 3) | Starlite/ChEMBL | References |
Homo sapiens | ADAM metallopeptidase with thrombospondin type 1 motif, 4 | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 14 (membrane-inserted) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 13 (collagenase 3) | 471 aa | 448 aa | 34.1 % |
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0201 | 0.0698 | 0.5 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0141 | 0.0283 | 0.1005 |
Entamoeba histolytica | kinesin, putative | 0.0201 | 0.0698 | 0.5 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0203 | 0.071 | 0.0824 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0141 | 0.0283 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0283 | 0.1005 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0257 | 0.1083 | 0.6186 |
Brugia malayi | Kinesin motor domain containing protein | 0.0201 | 0.0698 | 0.3396 |
Onchocerca volvulus | Matrilysin homolog | 0.0344 | 0.1684 | 1 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0141 | 0.0283 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.0443 | 0.0515 |
Onchocerca volvulus | 0.0164 | 0.0443 | 0.2123 | |
Brugia malayi | Matrixin family protein | 0.0367 | 0.1844 | 1 |
Mycobacterium ulcerans | hydrolase | 0.0141 | 0.0283 | 0.5 |
Echinococcus multilocularis | kinesin family 1 | 0.1548 | 1 | 1 |
Giardia lamblia | Kinesin-5 | 0.0201 | 0.0698 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0257 | 0.1083 | 0.5616 |
Loa Loa (eye worm) | matrixin family protein | 0.0367 | 0.1844 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 0.082 | 0.4097 |
Brugia malayi | Hemopexin family protein | 0.0164 | 0.0443 | 0.1927 |
Schistosoma mansoni | hypothetical protein | 0.1347 | 0.8611 | 1 |
Plasmodium vivax | kinesin-5 | 0.0201 | 0.0698 | 0.5 |
Schistosoma mansoni | kinesin eg-5 | 0.0201 | 0.0698 | 0.0811 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0201 | 0.0698 | 0.3396 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.071 | 0.3463 |
Plasmodium falciparum | kinesin-5 | 0.0201 | 0.0698 | 0.5 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0219 | 0.082 | 0.4097 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 48 nM | Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assay | ChEMBL. | 21536437 |
IC50 (binding) | = 1500 nM | Inhibition of ADAMTS-5 assessed as substrate cleavage after 16 hrs by fluorescence assay | ChEMBL. | 21536437 |
IC50 (binding) | > 10000 nM | Inhibition of recombinant human MMP-13 assessed as substrate cleavage after 20 hrs by fluorescence assay | ChEMBL. | 21536437 |
IC50 (binding) | > 10000 nM | Inhibition of recombinant human MMP-14 assessed as substrate cleavage after 20 hrs by fluorescence assay | ChEMBL. | 21536437 |
IC50 (binding) | > 10000 nM | Inhibition of recombinant human MMP-2 assessed as substrate cleavage after 20 hrs by fluorescence assay | ChEMBL. | 21536437 |
IC50 (binding) | > 10000 nM | Inhibition of recombinant human MMP-9 assessed as substrate cleavage after 20 hrs by fluorescence assay | ChEMBL. | 21536437 |
IC50 (binding) | > 10 uM | Inhibition of recombinant human MMP-1 assessed as substrate cleavage after 20 hrs by fluorescence assay | ChEMBL. | 21536437 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.