Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0139 | 0.1235 | 1 |
Schistosoma mansoni | NADH-ubiquinone oxidoreductase | 0.0139 | 0.1235 | 0.1235 |
Giardia lamblia | Deoxynucleoside kinase | 0.0139 | 0.1235 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0139 | 0.1235 | 1 |
Echinococcus multilocularis | NADH ubiquinone oxidoreductase 42 kDa subunit | 0.0139 | 0.1235 | 0.1235 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0139 | 0.1235 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0139 | 0.1235 | 1 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0071 | 0 | 0.5 |
Leishmania major | thymidylate kinase-like protein | 0.0071 | 0 | 0.5 |
Onchocerca volvulus | Putative thymidylate kinase | 0.0071 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0139 | 0.1235 | 1 |
Toxoplasma gondii | thymidylate kinase | 0.0071 | 0 | 0.5 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0139 | 0.1235 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0139 | 0.1235 | 1 |
Mycobacterium leprae | probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) | 0.0071 | 0 | 0.5 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0139 | 0.1235 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0139 | 0.1235 | 1 |
Schistosoma mansoni | thymidine kinase | 0.0621 | 1 | 1 |
Giardia lamblia | Deoxyguanosine kinase/deoxyadenosine kinase subunit, putative | 0.0139 | 0.1235 | 1 |
Echinococcus multilocularis | transfer RNA-Ile | 0.0621 | 1 | 1 |
Plasmodium vivax | thymidylate kinase, putative | 0.0071 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0071 | 0 | 0.5 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0071 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0139 | 0.1235 | 1 |
Brugia malayi | Deoxynucleoside kinase family protein | 0.0139 | 0.1235 | 1 |
Plasmodium falciparum | thymidylate kinase | 0.0071 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0139 | 0.1235 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0139 | 0.1235 | 1 |
Loa Loa (eye worm) | deoxynucleoside kinase | 0.0139 | 0.1235 | 1 |
Echinococcus granulosus | Thymidine kinase 2 mitochondrial | 0.0621 | 1 | 1 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0071 | 0 | 0.5 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0071 | 0 | 0.5 |
Echinococcus granulosus | thymidine kinase | 0.0621 | 1 | 1 |
Echinococcus granulosus | NADH ubiquinone oxidoreductase 42 kDa subunit | 0.0139 | 0.1235 | 0.1235 |
Echinococcus multilocularis | thymidine kinase | 0.0621 | 1 | 1 |
Chlamydia trachomatis | thymidylate kinase | 0.0071 | 0 | 0.5 |
Echinococcus multilocularis | thymidine kinase | 0.0621 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0139 | 0.1235 | 1 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0139 | 0.1235 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0139 | 0.1235 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0139 | 0.1235 | 1 |
Giardia lamblia | Hypothetical protein | 0.0139 | 0.1235 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0139 | 0.1235 | 1 |
Giardia lamblia | Hypothetical protein | 0.0139 | 0.1235 | 1 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0071 | 0 | 0.5 |
Mycobacterium ulcerans | thymidylate kinase | 0.0071 | 0 | 0.5 |
Mycobacterium tuberculosis | Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) | 0.0071 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0139 | 0.1235 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 56.04 % | Activity at human carbonic anhydrase 2 assessed as hydrolysis of p- nitrophenyl acetate at 0.3 umol/L at pH 7.6 | ChEMBL. | 21524585 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.