Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | insulin-like growth factor 1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0111 | 0.0504 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0842 | 1 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0111 | 0.0504 | 0.0504 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0504 | 0.4506 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0504 | 0.4506 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0111 | 0.0504 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0087 | 0.0202 | 0.1803 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0111 | 0.0504 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0842 | 1 | 1 |
Schistosoma mansoni | amine oxidase | 0.0111 | 0.0504 | 0.0504 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0504 | 0.4506 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0111 | 0.0504 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0185 | 0.1655 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0731 | 0.8561 | 1 |
Brugia malayi | hypothetical protein | 0.0111 | 0.0504 | 0.4506 |
Echinococcus multilocularis | 0.0111 | 0.0504 | 0.0504 | |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0111 | 0.0504 | 0.0504 |
Schistosoma mansoni | tyrosine kinase | 0.0158 | 0.112 | 0.112 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0504 | 0.4506 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0158 | 0.112 | 0.112 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0504 | 0.4506 |
Echinococcus granulosus | insulin receptor | 0.0158 | 0.112 | 0.1308 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0111 | 0.0504 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0111 | 0.0504 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0111 | 0.0504 | 0.0589 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0731 | 0.8561 | 1 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0842 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0158 | 0.112 | 0.112 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0842 | 1 | 1 |
Echinococcus multilocularis | insulin receptor | 0.0158 | 0.112 | 0.112 |
Brugia malayi | SWIRM domain containing protein | 0.0111 | 0.0504 | 0.4506 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0111 | 0.0504 | 0.4506 |
Onchocerca volvulus | 0.0111 | 0.0504 | 0.5 | |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0158 | 0.112 | 0.1308 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0111 | 0.0504 | 0.5 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0111 | 0.0504 | 0.0504 |
Brugia malayi | Protein kinase domain containing protein | 0.0158 | 0.112 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0111 | 0.0504 | 0.0589 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0111 | 0.0504 | 0.5 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0158 | 0.112 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0111 | 0.0504 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0111 | 0.0504 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0111 | 0.0504 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0504 | 0.4506 |
Leishmania major | UDP-galactopyranose mutase | 0.0111 | 0.0504 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.