Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0841 | 0.0841 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0025 | 0 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.1936 | 1 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0027 | 0.0396 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0035 | 0.1936 | 0.1936 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0029 | 0.0841 | 0.4346 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.1936 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0027 | 0.0396 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1936 | 0.1936 |
Echinococcus multilocularis | ectonucleotide | 0.0029 | 0.0841 | 0.4346 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.1936 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0396 | 1 |
Brugia malayi | Probable ATP-dependent helicase DHX35 | 0.0032 | 0.1305 | 0.1305 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0035 | 0.1936 | 0.1936 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF7 | 0.0027 | 0.0396 | 1 |
Plasmodium vivax | tubulin beta chain, putative | 0.0025 | 0 | 0.5 |
Giardia lamblia | Rrm3p helicase | 0.0027 | 0.0396 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.1936 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.1936 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 1 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0035 | 0.1936 | 0.1936 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.1936 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.1936 | 1 |
Echinococcus granulosus | ectonucleotide | 0.0029 | 0.0841 | 0.4346 |
Schistosoma mansoni | hypothetical protein | 0.0027 | 0.0396 | 0.0396 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.1936 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.1936 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1936 | 0.1936 |
Loa Loa (eye worm) | DEAH box polypeptide 35 | 0.0032 | 0.1305 | 0.1305 |
Plasmodium falciparum | tubulin beta chain | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1936 | 0.1936 |
Toxoplasma gondii | beta-tubulin, putative | 0.0025 | 0 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.1936 | 1 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0027 | 0.0396 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0035 | 0.1936 | 0.1936 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0027 | 0.0396 | 1 |
Toxoplasma gondii | beta tubulin | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0075 | 1 | 1 | |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF6, putative | 0.0027 | 0.0396 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1305 | 0.1305 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF6 | 0.0027 | 0.0396 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.1936 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase PIF1 | 0.0027 | 0.0396 | 0.2046 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0035 | 0.1936 | 0.1936 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0029 | 0.0841 | 0.4346 |
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.0027 | 0.0396 | 1 |
Echinococcus multilocularis | ATP dependent DNA helicase PIF1 | 0.0027 | 0.0396 | 0.2046 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0075 | 1 | 1 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0027 | 0.0396 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.5 ug ml-1 | Antifungal activity against Candida albicans ATCC 90028 assessed as inhibition of fungal growth by alamar blue assay | ChEMBL. | 21130660 |
IC50 (functional) | = 2 ug ml-1 | Antifungal activity against Cryptococcus neoformans ATCC 90113 assessed as inhibition of fungal growth by alamar blue assay | ChEMBL. | 21130660 |
MFC (functional) | > 20 ug ml-1 | Fungicidal activity against Candida albicans ATCC 90028 | ChEMBL. | 21130660 |
MFC (functional) | > 20 ug ml-1 | Fungicidal activity against Cryptococcus neoformans ATCC 90113 | ChEMBL. | 21130660 |
MIC (functional) | = 5 ug ml-1 | Antifungal activity against Cryptococcus neoformans ATCC 90113 by microscopy | ChEMBL. | 21130660 |
MIC (functional) | = 5.5 ug ml-1 | Antifungal activity against Candida albicans ATCC 90028 by microscopy | ChEMBL. | 21130660 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Cryptococcus neoformans | ChEMBL23 | 21130660 | |
Candida albicans | ChEMBL23 | 21130660 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.