Detailed information for compound 1525300

Basic information

Technical information
  • TDR Targets ID: 1525300
  • Name: [2-oxo-2-(pyridin-2-ylamino)ethyl]phosphonic acid
  • MW: 216.131 | Formula: C7H9N2O4P
  • H donors: 3 H acceptors: 5 LogP: -0.88 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CP(=O)(O)O)Nc1ccccn1
  • InChi: 1S/C7H9N2O4P/c10-7(5-14(11,12)13)9-6-3-1-2-4-8-6/h1-4H,5H2,(H,8,9,10)(H2,11,12,13)
  • InChiKey: NIQSVTFCYHYQQD-UHFFFAOYSA-N  

Network

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Synonyms

  • [2-oxo-2-(2-pyridylamino)ethyl]phosphonic acid
  • [2-keto-2-(2-pyridylamino)ethyl]phosphonic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi SEA domain containing protein 0.0044 0.0224 0.0224
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0052 0.039 0.0626
Leishmania major hypothetical protein, conserved 0.0073 0.0831 0.1658
Echinococcus granulosus glycoprotein Antigen 5 0.0044 0.0221 0.0637
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0221 0.0355
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0048 0.0308 0.0888
Mycobacterium ulcerans hypothetical protein 0.0044 0.0221 0.0137
Brugia malayi Trypsin family protein 0.0044 0.0221 0.0221
Echinococcus multilocularis glycoprotein Antigen 5 0.0044 0.0221 0.0637
Plasmodium vivax DNA topoisomerase II, putative 0.0149 0.2419 0.698
Echinococcus granulosus nmda type glutamate receptor 0.01 0.1401 0.4043
Loa Loa (eye worm) hypothetical protein 0.0194 0.3341 0.567
Echinococcus multilocularis glutamate receptor 2 0.0075 0.0863 0.2492
Schistosoma mansoni DNA topoisomerase type I 0.02 0.3465 0.5565
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0075 0.0863 0.2492
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0067 0.0716 0.1083
Schistosoma mansoni sodium/chloride dependent transporter 0.0194 0.3341 0.5366
Leishmania major hypothetical protein, conserved 0.0073 0.0831 0.1658
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0221 0.0355
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0141 0.2251 0.5585
Schistosoma mansoni hypothetical protein 0.0044 0.0221 0.0355
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0087 0.1126 0.1856
Brugia malayi Trypsin family protein 0.0044 0.0221 0.0221
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0075 0.0863 0.2492
Loa Loa (eye worm) DNA topoisomerase I 0.02 0.3465 0.5881
Echinococcus multilocularis glutamate receptor NMDA 0.0084 0.1067 0.3079
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0831 0.1658
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0087 0.1126 0.3075
Brugia malayi Muscle positioning protein 4 0.0044 0.0224 0.0224
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0075 0.0863 0.2492
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0168 0.2798 0.7888
Loa Loa (eye worm) hypothetical protein 0.0044 0.0221 0.0375
Onchocerca volvulus 0.0044 0.0224 0.038
Trypanosoma cruzi trypanothione reductase, putative 0.0067 0.0716 0.1293
Echinococcus multilocularis DNA topoisomerase 1 0.02 0.3465 1
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0831 0.1658
Brugia malayi DNA topoisomerase I 0.02 0.3465 0.3465
Loa Loa (eye worm) hypothetical protein 0.0061 0.0578 0.0982
Schistosoma mansoni hypothetical protein 0.0048 0.0308 0.0494
Echinococcus granulosus thioredoxin glutathione reductase 0.0067 0.0716 0.2066
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0071 0.0793 0.229
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0044 0.0221 0.0355
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0221 0.0355
Plasmodium vivax DNA gyrase subunit B, putative 0.0087 0.1126 0.3248
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0149 0.2419 0.2419
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0221 0.0355
Onchocerca volvulus 0.0044 0.0221 0.0375
Echinococcus granulosus amiloride sensitive amine oxidase 0.0091 0.1211 0.3496
Echinococcus multilocularis tissue type plasminogen activator 0.0048 0.0308 0.0888
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0194 0.3341 0.5366
Brugia malayi Protein kinase domain containing protein 0.0048 0.0308 0.0308
Leishmania major mitochondrial DNA topoisomerase II 0.0168 0.2798 0.7888
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0831 0.1658
Schistosoma mansoni ATP-binding cassette transporter 0.0058 0.0529 0.085
Brugia malayi glutathione reductase 0.0067 0.0716 0.0716
Schistosoma mansoni glutamate receptor AMPA 0.0058 0.0529 0.085
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.0221 0.0355
Echinococcus multilocularis nmda type glutamate receptor 0.01 0.1401 0.4043
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0168 0.2798 0.7888
Trypanosoma cruzi membrane transporter protein, putative 0.0073 0.0831 0.1658
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0087 0.1126 0.5
Loa Loa (eye worm) TK/ROR protein kinase 0.0048 0.0308 0.0522
Onchocerca volvulus 0.0044 0.0224 0.038
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0075 0.0863 0.2492
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0039 0.0135 0.0391
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0039 0.0135 0.023
Toxoplasma gondii kringle domain-containing protein 0.0048 0.0308 0.0888
Brugia malayi Probable DNA topoisomerase II 0.0149 0.2419 0.2419
Onchocerca volvulus 0.0044 0.0224 0.038
Trypanosoma brucei membrane transporter protein, putative 0.0073 0.0831 0.0419
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.0221 0.0355
Plasmodium vivax topoisomerase I, putative 0.02 0.3465 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0317 0.5892 0.9463
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0831 0.1658
Schistosoma mansoni hypothetical protein 0.0044 0.0224 0.0359
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0149 0.2419 0.698
Echinococcus granulosus transmembrane protease serine 3 0.0044 0.0221 0.0637
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0149 0.2419 0.2419
Loa Loa (eye worm) hypothetical protein 0.0101 0.1416 0.2403
Loa Loa (eye worm) hypothetical protein 0.0044 0.0221 0.0375
Chlamydia trachomatis glutamine binding protein 0.004 0.0142 0.1261
Echinococcus multilocularis glutamate receptor 2 0.0043 0.0212 0.0612
Plasmodium falciparum DNA gyrase subunit B 0.0087 0.1126 0.3248
Loa Loa (eye worm) hypothetical protein 0.0048 0.0308 0.0522
Loa Loa (eye worm) solute carrier family 6 member 4 0.0194 0.3341 0.567
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0831 0.1658
Loa Loa (eye worm) glutamate receptor 1 0.0058 0.0529 0.0899
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0044 0.0221 0.0221
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0101 0.1413 0.2398
Schistosoma mansoni DNA topoisomerase II 0.0149 0.2419 0.3884
Brugia malayi Kringle domain containing protein 0.0048 0.0308 0.0308
Schistosoma mansoni multidrug resistance protein 0.0073 0.0831 0.1335
Echinococcus granulosus Mastin 0.0044 0.0221 0.0637
Loa Loa (eye worm) DOMON domain-containing protein 0.0044 0.0224 0.038
Schistosoma mansoni hypothetical protein 0.0044 0.0221 0.0355
Echinococcus granulosus serotonin transporter 0.0194 0.3341 0.9642
Brugia malayi Glutamate receptor 1 precursor 0.0058 0.0529 0.0529
Schistosoma mansoni DNA topoisomerase type I 0.02 0.3465 0.5565
Entamoeba histolytica DNA topoisomerase II, putative 0.0149 0.2419 0.5
Trypanosoma brucei MATE efflux family protein, putative 0.0073 0.0831 0.0419
Onchocerca volvulus 0.0044 0.0224 0.038
Echinococcus multilocularis enteropeptidase 0.0044 0.0221 0.0637
Loa Loa (eye worm) hypothetical protein 0.0194 0.3341 0.567
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0075 0.0863 0.2492
Echinococcus granulosus glutamate receptor 2 0.0043 0.0212 0.0612
Loa Loa (eye worm) hypothetical protein 0.0044 0.0221 0.0375
Loa Loa (eye worm) glutamate receptor 2 0.0058 0.0529 0.0899
Trypanosoma brucei membrane transporter protein, putative 0.0073 0.0831 0.0419
Schistosoma mansoni hypothetical protein 0.0091 0.1211 0.1946
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0101 0.1413 0.2398
Plasmodium falciparum glutathione reductase 0.0067 0.0716 0.2066
Brugia malayi Glutamate receptor 2 precursor 0.0058 0.0529 0.0529
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0044 0.0221 0.0637
Chlamydia trachomatis DNA gyrase subunit B 0.0069 0.0746 0.6627
Loa Loa (eye worm) serotonin transporter b 0.0194 0.3341 0.567
Chlamydia trachomatis DNA gyrase subunit B 0.0087 0.1126 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0039 0.0135 0.0391
Loa Loa (eye worm) thioredoxin reductase 0.0067 0.0716 0.1215
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0075 0.0863 0.2492
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0221 0.0355
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0221 0.0355
Schistosoma mansoni copper/topaquinone oxidase 0.0091 0.1211 0.1946
Echinococcus multilocularis nmda type glutamate receptor 0.0155 0.2543 0.734
Plasmodium vivax glutathione reductase, putative 0.0067 0.0716 0.2066
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.0221 0.0355
Loa Loa (eye worm) hypothetical protein 0.0034 0.0027 0.0046
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0101 0.1413 0.2398
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0039 0.0123 0.5
Echinococcus multilocularis amiloride sensitive amine oxidase 0.0091 0.1211 0.3496
Onchocerca volvulus 0.0044 0.0221 0.0375
Brugia malayi Thioredoxin reductase 0.0067 0.0716 0.0716
Echinococcus multilocularis serotonin transporter 0.0194 0.3341 0.9642
Echinococcus multilocularis multidrug and toxin extrusion protein 2 0.0073 0.0831 0.2399
Plasmodium falciparum thioredoxin reductase 0.0067 0.0716 0.2066
Plasmodium falciparum cysteine repeat modular protein 1 0.0048 0.0308 0.0888
Brugia malayi Trypsin-like protease protein 5 0.0044 0.0221 0.0221
Schistosoma mansoni glutamate receptor kainate 0.0058 0.0529 0.085
Toxoplasma gondii thioredoxin reductase 0.0067 0.0716 0.2066
Schistosoma mansoni glutamate receptor kainate 0.0058 0.0529 0.085
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0317 0.5906 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0221 0.0355
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0141 0.2251 0.5585
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0117 0.1754 0.5063
Giardia lamblia DNA topoisomerase II 0.0142 0.2257 0.5
Plasmodium vivax thioredoxin reductase, putative 0.0067 0.0716 0.2066
Leishmania major acetyltransferase-like protein 0.0111 0.1624 0.4169
Schistosoma mansoni amine GPCR 0.02 0.3467 0.5568
Trichomonas vaginalis DNA topoisomerase II, putative 0.0149 0.2419 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.1416 0.2403
Echinococcus granulosus tissue type plasminogen activator 0.0048 0.0308 0.0888
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0211 0.0338
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.02 0.3465 1
Onchocerca volvulus 0.0044 0.0221 0.0375
Toxoplasma gondii DNA topoisomerase 2, putative 0.0149 0.2419 0.698
Schistosoma mansoni glutamate receptor NMDA 0.0117 0.1754 0.2818
Mycobacterium ulcerans acetyltransferase 0.0111 0.1624 0.2571
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0039 0.0135 0.0135
Trypanosoma brucei DNA topoisomerase ii 0.0168 0.2798 0.7575
Schistosoma mansoni glutamate receptor kainate 0.0058 0.0529 0.085
Leishmania major DNA topoisomerase IB, large subunit 0.02 0.3465 1
Schistosoma mansoni glutamate receptor NMDA 0.0159 0.2613 0.4198
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.0221 0.0355
Schistosoma mansoni DNA topoisomerase type I 0.02 0.3465 0.5565
Trypanosoma cruzi DNA topoisomerase II, putative 0.0141 0.2251 0.6156
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0333 0.6226 1
Toxoplasma gondii hypothetical protein 0.0046 0.0274 0.0791
Loa Loa (eye worm) hypothetical protein 0.0061 0.0578 0.0982
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0087 0.1126 0.3248
Loa Loa (eye worm) TOPoisomerase family member 0.0149 0.2419 0.4105
Plasmodium falciparum topoisomerase I 0.02 0.3465 1
Echinococcus granulosus glutamate receptor 2 0.0075 0.0863 0.2492
Onchocerca volvulus 0.0044 0.0224 0.038
Onchocerca volvulus 0.0044 0.0221 0.0375
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.02 0.3465 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0224 0.038
Schistosoma mansoni glutamate receptor AMPA 0.0058 0.0529 0.085
Loa Loa (eye worm) hypothetical protein 0.0194 0.3341 0.567
Onchocerca volvulus 0.0273 0.4988 0.8466
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0075 0.0863 0.2492
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0044 0.0221 0.0637
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0221 0.0355
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0044 0.0221 0.0637
Loa Loa (eye worm) trypsin family protein 0.0044 0.0221 0.0375
Loa Loa (eye worm) hypothetical protein 0.0044 0.0224 0.038
Plasmodium falciparum DNA topoisomerase 2 0.0149 0.2419 0.698
Onchocerca volvulus 0.0194 0.3341 0.567
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0221 0.0355
Leishmania major trypanothione reductase 0.0067 0.0716 0.1293
Echinococcus multilocularis Mastin 0.0044 0.0221 0.0637
Loa Loa (eye worm) glutathione reductase 0.0067 0.0716 0.1215
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0211 0.0338
Echinococcus granulosus enteropeptidase 0.0044 0.0221 0.0637
Loa Loa (eye worm) hypothetical protein 0.0044 0.0221 0.0375
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0044 0.0221 0.0637
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0221 0.0355
Onchocerca volvulus 0.0048 0.0308 0.0522
Echinococcus multilocularis thioredoxin glutathione reductase 0.0067 0.0716 0.2066
Loa Loa (eye worm) hypothetical protein 0.0317 0.5892 1
Loa Loa (eye worm) hypothetical protein 0.0317 0.5892 1
Onchocerca volvulus 0.0044 0.0221 0.0375
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0221 0.0355
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0317 0.5906 1
Leishmania major DNA topoisomerase ii 0.0141 0.2251 0.6156
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.004 0.0142 0.1261
Echinococcus multilocularis transmembrane protease serine 3 0.0044 0.0221 0.0637
Toxoplasma gondii DNA topoisomerase I, putative 0.02 0.3465 1
Echinococcus multilocularis Multi antimicrobial extrusion protein MatE 0.0067 0.0698 0.2016
Echinococcus multilocularis glutamate receptor 2 0.0058 0.0529 0.1528
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0295 0.5442 1
Trypanosoma brucei membrane transporter protein, putative 0.0073 0.0831 0.0419
Loa Loa (eye worm) hypothetical protein 0.0044 0.0221 0.0375
Echinococcus granulosus glutamate NMDA receptor subunit 0.0117 0.1754 0.5063
Echinococcus granulosus multidrug and toxin extrusion protein 2 0.0073 0.0831 0.2399
Treponema pallidum sodium- and chloride- dependent transporter 0.0194 0.3341 1
Brugia malayi Trypsin family protein 0.0317 0.5892 0.5892
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0149 0.2419 0.698
Echinococcus granulosus glutamate receptor NMDA 0.0084 0.1067 0.3079
Echinococcus granulosus DNA topoisomerase 1 0.02 0.3465 1
Loa Loa (eye worm) norepinephrine transporter 0.0194 0.3341 0.567
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0075 0.0863 0.2492
Onchocerca volvulus 0.0317 0.5892 1
Echinococcus granulosus nmda type glutamate receptor 0.0155 0.2543 0.734
Brugia malayi Trypsin family protein 0.0044 0.0221 0.0221
Trypanosoma cruzi DNA topoisomerase II, putative 0.0141 0.2251 0.6156
Mycobacterium ulcerans DNA gyrase subunit B 0.0087 0.1126 0.1706
Brugia malayi hypothetical protein 0.0044 0.0221 0.0221
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0194 0.3341 0.3341

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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