Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Steroid receptor seven-up type 2 | 0.0081 | 0.0308 | 0.4223 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0081 | 0.0308 | 0.4223 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0554 | 0.3959 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1338 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0529 | 0.3766 | 0.3344 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0081 | 0.0308 | 0.4223 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0308 | 0.4295 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0134 | 0.0716 | 0.178 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0284 | 0.1874 | 0.031 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0134 | 0.0716 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0014 | 0.0195 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0081 | 0.0308 | 0.4295 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0308 | 0.4295 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0081 | 0.0308 | 0.4223 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0043 | 0.0014 | 0.0072 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0081 | 0.0308 | 0.4223 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0554 | 0.3959 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0014 | 0.0072 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0308 | 0.4295 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0081 | 0.0308 | 0.4295 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0081 | 0.0308 | 0.4223 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0081 | 0.0308 | 0.0744 |
Schistosoma mansoni | thyroid hormone receptor | 0.0081 | 0.0308 | 0.0744 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0081 | 0.0308 | 0.4223 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0081 | 0.0308 | 0.4223 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1068 | 0.7915 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0081 | 0.0308 | 0.0744 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0308 | 0.4295 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0081 | 0.0308 | 0.4223 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0081 | 0.0308 | 0.4223 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0081 | 0.0308 | 0.4295 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0081 | 0.0308 | 0.4223 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0081 | 0.0308 | 0.4223 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0134 | 0.0716 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0043 | 0.0014 | 0.0072 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0081 | 0.0308 | 0.0744 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0043 | 0.0014 | 0.0072 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0081 | 0.0308 | 0.0744 |
Echinococcus granulosus | carbonic anhydrase II | 0.0134 | 0.0716 | 1 |
Onchocerca volvulus | Putative sulfate transporter | 0.0224 | 0.1413 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0308 | 0.4295 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0081 | 0.0308 | 0.4223 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0043 | 0.0014 | 0.0195 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0554 | 0.3959 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0014 | 0.0072 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0308 | 0.4295 |
Brugia malayi | nuclear receptor RXR | 0.0043 | 0.0014 | 0.0072 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0134 | 0.0716 | 0.178 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0081 | 0.0308 | 0.4223 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0081 | 0.0308 | 0.4223 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0081 | 0.0308 | 0.4223 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0081 | 0.0308 | 0.4223 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0081 | 0.0308 | 0.0744 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0081 | 0.0308 | 0.4223 |
Schistosoma mansoni | carbonic anhydrase | 0.0554 | 0.3959 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0081 | 0.0308 | 0.4223 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0014 | 0.0195 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0081 | 0.0308 | 0.4295 |
Brugia malayi | steroid hormone receptor | 0.0081 | 0.0308 | 0.4223 |
Brugia malayi | nuclear receptor NHR-88 | 0.0081 | 0.0308 | 0.4223 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0081 | 0.0308 | 0.4223 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0081 | 0.0308 | 0.4223 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0134 | 0.0716 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0134 | 0.0716 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0081 | 0.0308 | 0.4295 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0081 | 0.0308 | 0.4295 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0081 | 0.0308 | 0.4223 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0081 | 0.0308 | 0.4295 |
Onchocerca volvulus | 0.0224 | 0.1413 | 1 | |
Brugia malayi | nuclear hormone receptor | 0.0081 | 0.0308 | 0.4223 |
Schistosoma mansoni | thyroid hormone receptor | 0.0081 | 0.0308 | 0.0744 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0081 | 0.0308 | 0.4295 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0134 | 0.0716 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0308 | 0.4295 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0134 | 0.0716 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0081 | 0.0308 | 0.4223 |
Schistosoma mansoni | nuclear hormone receptor | 0.0081 | 0.0308 | 0.0744 |
Brugia malayi | ecdysteroid receptor | 0.0081 | 0.0308 | 0.4223 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0081 | 0.0308 | 0.4223 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1338 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0308 | 0.4295 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0081 | 0.0308 | 0.4223 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0081 | 0.0308 | 0.0744 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0081 | 0.0308 | 0.4223 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0081 | 0.0308 | 0.0744 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0081 | 0.0308 | 0.4223 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0014 | 0.0195 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0081 | 0.0308 | 0.0744 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0081 | 0.0308 | 0.4223 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0014 | 0.0195 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0081 | 0.0308 | 0.4223 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0134 | 0.0716 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0014 | 0.0195 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0081 | 0.0308 | 0.4223 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0081 | 0.0308 | 0.4223 |
Schistosoma mansoni | coup transcription factor | 0.0081 | 0.0308 | 0.0744 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0081 | 0.0308 | 0.4223 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0081 | 0.0308 | 0.4223 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0043 | 0.0014 | 0.0072 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0134 | 0.0716 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0081 | 0.0308 | 0.0744 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0081 | 0.0308 | 0.4223 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 8410986 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.