Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0335 | 0.585 | 0.5758 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.585 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0335 | 0.585 | 0.5758 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0335 | 0.585 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0177 | 0.2418 | 0.225 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.2418 | 0.4133 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0158 | 0.2006 | 0.3177 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.585 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0158 | 0.2006 | 0.3177 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0335 | 0.585 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0335 | 0.585 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0335 | 0.585 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0335 | 0.585 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0177 | 0.2418 | 0.4133 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0335 | 0.585 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0335 | 0.585 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.2418 | 0.4133 |
Echinococcus granulosus | FTZ F1 alpha | 0.0335 | 0.585 | 0.5758 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0071 | 0.0109 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0335 | 0.585 | 1 |
Brugia malayi | ecdysone receptor | 0.0158 | 0.2006 | 0.3177 |
Schistosoma mansoni | zinc finger protein | 0.0158 | 0.2006 | 0.2989 |
Schistosoma mansoni | nuclear receptor | 0.0158 | 0.2006 | 0.2989 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0335 | 0.585 | 0.5758 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0158 | 0.2006 | 0.1829 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0335 | 0.585 | 1 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0158 | 0.2006 | 0.3177 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0335 | 0.585 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0158 | 0.2006 | 0.1829 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0335 | 0.585 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0335 | 0.585 | 0.5758 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0335 | 0.585 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0335 | 0.585 | 0.5758 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2006 | 0.343 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0335 | 0.585 | 1 |
Loa Loa (eye worm) | DR-78 | 0.0158 | 0.2006 | 0.343 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0158 | 0.2006 | 0.1829 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0158 | 0.2006 | 0.3177 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0335 | 0.585 | 0.5758 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0335 | 0.585 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0335 | 0.585 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0526 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0335 | 0.585 | 1 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0158 | 0.2006 | 0.2989 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0158 | 0.2006 | 0.343 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0158 | 0.2006 | 0.1829 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0335 | 0.585 | 0.5758 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0335 | 0.585 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0158 | 0.2006 | 0.343 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0158 | 0.2006 | 0.3177 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2006 | 0.343 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2006 | 0.343 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0335 | 0.585 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0177 | 0.2418 | 0.374 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0335 | 0.585 | 1 |
Brugia malayi | steroid hormone receptor | 0.0335 | 0.585 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0335 | 0.585 | 0.5758 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2006 | 0.343 |
Brugia malayi | nuclear receptor RXR | 0.0158 | 0.2006 | 0.3177 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0335 | 0.585 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0335 | 0.585 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0335 | 0.585 | 1 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0158 | 0.2006 | 0.1829 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2006 | 0.343 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0177 | 0.2418 | 0.225 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0158 | 0.2006 | 0.1829 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0158 | 0.2006 | 0.3177 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0177 | 0.2418 | 0.374 |
Brugia malayi | nuclear hormone receptor | 0.0158 | 0.2006 | 0.3177 |
Brugia malayi | hypothetical protein | 0.0177 | 0.2418 | 0.3907 |
Onchocerca volvulus | 0.0335 | 0.585 | 1 | |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0335 | 0.585 | 0.5758 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0335 | 0.585 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0158 | 0.2006 | 0.1829 |
Brugia malayi | nuclear receptor RXR | 0.0177 | 0.2418 | 0.3907 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0158 | 0.2006 | 0.1829 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0158 | 0.2006 | 0.1829 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2006 | 0.343 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2006 | 0.343 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2006 | 0.343 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2006 | 0.343 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.585 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0335 | 0.585 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.585 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0335 | 0.585 | 0.5758 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.585 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0158 | 0.2006 | 0.1829 |
Schistosoma mansoni | coup transcription factor | 0.0335 | 0.585 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0177 | 0.2418 | 0.3907 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0335 | 0.585 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2006 | 0.343 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2006 | 0.343 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0335 | 0.585 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0335 | 0.585 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0071 | 0.0109 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.585 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0335 | 0.585 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0335 | 0.585 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.585 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0158 | 0.2006 | 0.2989 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0335 | 0.585 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0158 | 0.2006 | 0.1829 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0335 | 0.585 | 0.5758 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.2418 | 0.4133 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0335 | 0.585 | 0.5758 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0335 | 0.585 | 0.5758 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0177 | 0.2418 | 0.3907 |
Schistosoma mansoni | nuclear hormone receptor | 0.0158 | 0.2006 | 0.2989 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0158 | 0.2006 | 0.343 |
Brugia malayi | nuclear hormone receptor | 0.0335 | 0.585 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0158 | 0.2006 | 0.1829 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0335 | 0.585 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0158 | 0.2006 | 0.2989 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0335 | 0.585 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0335 | 0.585 | 0.5758 |
Brugia malayi | tailless protein | 0.0158 | 0.2006 | 0.3177 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0335 | 0.585 | 0.5758 |
Brugia malayi | hypothetical protein | 0.0158 | 0.2006 | 0.3177 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0335 | 0.585 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.585 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0335 | 0.585 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2006 | 0.343 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0158 | 0.2006 | 0.2989 |
Brugia malayi | nuclear receptor NHR-88 | 0.0158 | 0.2006 | 0.3177 |
Schistosoma mansoni | thyroid hormone receptor | 0.0335 | 0.585 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.2006 | 0.343 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.2418 | 0.4133 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0335 | 0.585 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0158 | 0.2006 | 0.2989 |
Schistosoma mansoni | nuclear hormone receptor | 0.0335 | 0.585 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0335 | 0.585 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0335 | 0.585 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0335 | 0.585 | 0.5758 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.2418 | 0.4133 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0335 | 0.585 | 1 |
Brugia malayi | conserved hypotetical protein | 0.0158 | 0.2006 | 0.3177 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0335 | 0.585 | 0.5758 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0076 | 0.0217 | 0.0371 |
Brugia malayi | hypothetical protein | 0.0177 | 0.2418 | 0.3907 |
Brugia malayi | ecdysteroid receptor | 0.0335 | 0.585 | 1 |
Brugia malayi | hypothetical protein | 0.0158 | 0.2006 | 0.3177 |
Brugia malayi | nuclear receptor NHR-67 | 0.0158 | 0.2006 | 0.3177 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 95 % | Cytotoxicity against LPS-stimulated mouse RAW264.7 cells assessed as cell viability at 1 to 25 uM pretreated for 15 mins before LPS challenge measured after 24 hrs by MTT assay | ChEMBL. | 21334121 |
IC50 (functional) | > 25 uM | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide release pretreated for 15 mins before LPS challenge measured after 24 hrs by Griess method | ChEMBL. | 21334121 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.