Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 8 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Stress-activated protein kinase jnk-1 | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Echinococcus granulosus | c-Jun N-terminal kinases | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Schistosoma japonicum | ko:K04440 c-Jun N-terminal kinase, putative | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Schistosoma japonicum | IPR000164,Histone H3;IPR009072,Histone-fold,domain-containing | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0118 | 0.3295 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1322 | 0.1348 |
Giardia lamblia | Aurora kinase | 0.0118 | 0.3295 | 0.5 |
Onchocerca volvulus | 0.0021 | 0 | 0.5 | |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.01 | 0.2678 | 0.2732 |
Echinococcus granulosus | aurora kinase A | 0.0118 | 0.3295 | 0.3361 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.1237 | 0.1262 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0118 | 0.3295 | 0.3295 |
Echinococcus multilocularis | 0.0095 | 0.2524 | 0.2574 | |
Schistosoma mansoni | ryanodine receptor 1 skeletal muscle | 0.0036 | 0.0519 | 0.0519 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0167 | 0.4959 | 0.5057 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0118 | 0.3295 | 0.3361 |
Brugia malayi | Stress-activated protein kinase jnk-1 | 0.028 | 0.8811 | 0.8811 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0118 | 0.3295 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.028 | 0.8811 | 0.8811 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.1925 | 0.1925 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0167 | 0.4959 | 0.5057 |
Loa Loa (eye worm) | AUR protein kinase | 0.0118 | 0.3295 | 0.3361 |
Echinococcus granulosus | insulin receptor | 0.01 | 0.2678 | 0.2732 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0255 | 0.796 | 0.8119 |
Loa Loa (eye worm) | AUR protein kinase | 0.0118 | 0.3295 | 0.3361 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0118 | 0.3295 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0118 | 0.3295 | 1 |
Entamoeba histolytica | protein kinase , putative | 0.0118 | 0.3295 | 1 |
Loa Loa (eye worm) | ryanodine receptor | 0.0074 | 0.1812 | 0.1848 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0255 | 0.796 | 0.8119 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0118 | 0.3295 | 0.3295 |
Echinococcus multilocularis | insulin receptor | 0.01 | 0.2678 | 0.2732 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0096 | 0.2559 | 0.2559 |
Schistosoma mansoni | tyrosine kinase | 0.0167 | 0.4959 | 0.4959 |
Schistosoma mansoni | ryanodine receptor related | 0.0315 | 1 | 1 |
Echinococcus multilocularis | aurora kinase A | 0.0118 | 0.3295 | 0.3361 |
Loa Loa (eye worm) | AUR protein kinase | 0.0118 | 0.3295 | 0.3361 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0199 | 0.6051 | 0.6172 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0309 | 0.9805 | 1 |
Loa Loa (eye worm) | ryanodine receptor | 0.0118 | 0.3286 | 0.3351 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0118 | 0.3295 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.6051 | 0.6172 |
Entamoeba histolytica | protein kinase, putative | 0.0118 | 0.3295 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0118 | 0.3295 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0164 | 0.485 | 0.485 |
Brugia malayi | Protein kinase domain containing protein | 0.01 | 0.2678 | 0.2678 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0118 | 0.3295 | 0.3295 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | 0.028 | 0.8811 | 0.8987 |
Schistosoma mansoni | tyrosine kinase | 0.0164 | 0.485 | 0.485 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0118 | 0.3295 | 1 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0038 | 0.0588 | 0.0588 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0118 | 0.3295 | 0.5 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.01 | 0.2678 | 0.2732 |
Trichomonas vaginalis | AGC family protein kinase | 0.0118 | 0.3295 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0309 | 0.9805 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0167 | 0.4959 | 0.4959 |
Trichomonas vaginalis | AGC family protein kinase | 0.0118 | 0.3295 | 1 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.01 | 0.2678 | 0.2732 |
Trypanosoma brucei | aurora B kinase | 0.0118 | 0.3295 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0118 | 0.3295 | 0.3361 |
Schistosoma mansoni | tyrosine kinase | 0.01 | 0.2678 | 0.2678 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | 0.028 | 0.8811 | 0.8987 |
Schistosoma mansoni | tyrosine kinase | 0.0164 | 0.485 | 0.485 |
Echinococcus granulosus | c-Jun N-terminal kinases | 0.028 | 0.8811 | 0.8987 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0588 | 0.0599 |
Schistosoma mansoni | tyrosine kinase | 0.01 | 0.2678 | 0.2678 |
Toxoplasma gondii | aurora kinase | 0.0118 | 0.3295 | 0.5 |
Brugia malayi | serine/threonine kinase 12 | 0.0118 | 0.3295 | 0.3295 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0199 | 0.6051 | 0.6172 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0167 | 0.4959 | 0.5057 |
Leishmania major | protein kinase, putative | 0.0118 | 0.3295 | 1 |
Schistosoma mansoni | protein kinase | 0.0118 | 0.3295 | 0.3295 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0309 | 0.9805 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0118 | 0.3295 | 1 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0309 | 0.9805 | 0.9805 |
Brugia malayi | cation channel family protein | 0.0135 | 0.3864 | 0.3864 |
Schistosoma mansoni | tyrosine kinase | 0.0309 | 0.9805 | 0.9805 |
Entamoeba histolytica | protein kinase, putative | 0.0118 | 0.3295 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.8 uM | Inhibition of JNK1 by TR-FRET assay | ChEMBL. | 21458276 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.