Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase kinase kinase 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0183 | 0.3088 | 0.2479 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0111 | 0.1788 | 0.1064 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0183 | 0.3088 | 0.2479 |
Brugia malayi | Neuronal symmetry protein 1 | 0.0249 | 0.4284 | 0.5976 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0183 | 0.3088 | 0.4029 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.0127 | 0.2072 | 0.5 |
Trichomonas vaginalis | cdc25c, putative | 0.0111 | 0.1788 | 0.1064 |
Schistosoma mansoni | protein kinase | 0.0249 | 0.4284 | 0.7182 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0111 | 0.1788 | 0.1064 |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.0183 | 0.3088 | 0.3112 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0075 | 0.1153 | 1 |
Trichomonas vaginalis | cdc25b, putative | 0.0111 | 0.1788 | 0.1064 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1788 | 0.1331 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0249 | 0.4284 | 0.5976 |
Trypanosoma brucei | low molecular weight protein tyrosine phosphatase, putative | 0.0056 | 0.081 | 0.5 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0183 | 0.3088 | 0.2479 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0343 | 0.5964 | 1 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0111 | 0.1788 | 0.1064 |
Schistosoma mansoni | protein kinase | 0.0249 | 0.4284 | 0.7182 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0183 | 0.3088 | 0.1583 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0111 | 0.1788 | 0.1064 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0183 | 0.3088 | 0.2479 |
Schistosoma mansoni | m-phase inducer phosphatase(cdc25) | 0.0111 | 0.1788 | 0.2997 |
Trichomonas vaginalis | pps1 dual specificty phosphatase, putative | 0.0567 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1632 | 0.1008 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1632 | 0.1008 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0343 | 0.5964 | 1 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0111 | 0.1788 | 0.1064 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0183 | 0.3088 | 0.5 |
Loa Loa (eye worm) | STE/STE11/ASK protein kinase | 0.0075 | 0.1153 | 0.0014 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0183 | 0.3088 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1788 | 0.1331 |
Leishmania major | hypothetical protein, conserved | 0.0056 | 0.081 | 0.5 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0183 | 0.3088 | 0.1583 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0249 | 0.4284 | 0.5976 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0343 | 0.5964 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0343 | 0.5964 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0343 | 0.5964 | 1 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0183 | 0.3088 | 0.2479 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.4277 | 0.6498 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0183 | 0.3088 | 0.2479 |
Onchocerca volvulus | 0.0183 | 0.3088 | 1 | |
Trichomonas vaginalis | cdc25b, putative | 0.0111 | 0.1788 | 0.1064 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0075 | 0.1153 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.7 uM | Competitive inhibition of human ASK1 | ChEMBL. | 21449566 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.