Detailed information for compound 1528566

Basic information

Technical information
  • TDR Targets ID: 1528566
  • Name: N-(3-cyano-5,6-dihydro-4H-cyclopenta[d]thioph en-2-yl)-2-[[4-(2-methoxyethyl)-1,2,4-triazol -3-yl]sulfanyl]acetamide
  • MW: 363.458 | Formula: C15H17N5O2S2
  • H donors: 1 H acceptors: 4 LogP: 1.93 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCn1cnnc1SCC(=O)Nc1sc2c(c1C#N)CCC2
  • InChi: 1S/C15H17N5O2S2/c1-22-6-5-20-9-17-19-15(20)23-8-13(21)18-14-11(7-16)10-3-2-4-12(10)24-14/h9H,2-6,8H2,1H3,(H,18,21)
  • InChiKey: XMJVSABXSCLTPC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-cyano-5,6-dihydro-4H-cyclopenta[d]thiophen-2-yl)-2-[[4-(2-methoxyethyl)-1,2,4-triazol-3-yl]thio]acetamide
  • N-(3-cyano-5,6-dihydro-4H-cyclopenta[d]thiophen-2-yl)-2-[[4-(2-methoxyethyl)-1,2,4-triazol-3-yl]sulfanyl]ethanamide
  • ZINC03351314
  • T5325383

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0068 0.1704 0.5
Schistosoma mansoni glutamate receptor NMDA 0.0058 0.097 0.0373
Echinococcus granulosus glutamate receptor NMDA 0.0084 0.2911 0.2911
Schistosoma mansoni glutamate receptor NMDA 0.0155 0.8296 1
Schistosoma mansoni glutamate receptor AMPA 0.0058 0.097 0.0373
Echinococcus multilocularis nmda type glutamate receptor 0.0177 1 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0071 0.1989 0.1989
Echinococcus granulosus glutamate NMDA receptor subunit 0.0058 0.097 0.097
Brugia malayi Glutamate receptor 1 precursor 0.0058 0.097 1
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0068 0.1704 0.5
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0071 0.1989 0.1989
Leishmania major DNA polymerase eta, putative 0.0054 0.0686 0.5
Echinococcus multilocularis glutamate receptor 2 0.0058 0.097 0.097
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0071 0.1989 0.1989
Chlamydia trachomatis glutamine binding protein 0.0068 0.1704 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0774 0.0774
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0774 0.3112
Schistosoma mansoni ATP-binding cassette transporter 0.0058 0.097 0.0373
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0774 0.0116
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0071 0.1989 0.1989
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0774 0.0774
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0094 0.3693 0.3693
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0774 0.0774
Echinococcus granulosus nmda type glutamate receptor 0.0097 0.3931 0.3931
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0071 0.1989 0.1989
Echinococcus multilocularis nmda type glutamate receptor 0.0097 0.3931 0.3931
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0068 0.1704 0.5
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0686 0.5
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0071 0.1989 0.1989
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0068 0.1704 0.5
Echinococcus granulosus dna polymerase eta 0.0054 0.0686 0.0686
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0774 0.3112
Echinococcus multilocularis glutamate receptor 2 0.0071 0.1989 0.1989
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0068 0.1704 0.5
Echinococcus multilocularis dna polymerase eta 0.0054 0.0686 0.0686
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0774 0.0116
Echinococcus granulosus glutamate receptor 2 0.0071 0.1989 0.1989
Schistosoma mansoni glutamate receptor kainate 0.0058 0.097 0.0373
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0774 0.0116
Echinococcus multilocularis glutamate receptor NMDA 0.0084 0.2911 0.2911
Schistosoma mansoni glutamate receptor AMPA 0.0058 0.097 0.0373
Loa Loa (eye worm) glutamate receptor 2 0.0058 0.097 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0774 0.0774
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0686 0.5
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0071 0.1989 0.1989
Brugia malayi Glutamate receptor 2 precursor 0.0058 0.097 1
Schistosoma mansoni glutamate receptor kainate 0.0058 0.097 0.0373
Loa Loa (eye worm) glutamate receptor 1 0.0058 0.097 1
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0071 0.1989 0.1989
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0058 0.097 0.097
Schistosoma mansoni glutamate receptor kainate 0.0058 0.097 0.0373

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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