Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Homo sapiens | Rap guanine nucleotide exchange factor (GEF) 4 | Starlite/ChEMBL | No references |
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | Starlite/ChEMBL | No references |
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | No references |
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Mycobacterium tuberculosis | UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | tumor susceptibility 101 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0014 | 0.003 | 0.003 |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 0.1067 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.003 | 0.0283 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 0.1067 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.1067 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.1067 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.046 | 0.4307 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0056 | 0.0472 | 0.4241 |
Schistosoma mansoni | tsg101-related | 0.0057 | 0.0479 | 0.4489 |
Mycobacterium ulcerans | UDP-galactopyranose mutase Glf | 0.0688 | 0.6992 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0756 | 0.3534 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.1067 | 1 |
Entamoeba histolytica | tumor susceptibility gene 101 protein, putative | 0.0057 | 0.0479 | 0.4306 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.1067 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0204 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.214 | 1 |
Onchocerca volvulus | 0.0182 | 0.1773 | 0.8286 | |
Brugia malayi | hypothetical protein | 0.0182 | 0.1773 | 0.8286 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0218 | 0.214 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.1773 | 0.8286 |
Brugia malayi | hypothetical protein | 0.0084 | 0.0756 | 0.3534 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.1067 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.046 | 0.4307 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0204 | 0.5 |
Brugia malayi | hypothetical protein | 0.002 | 0.0092 | 0.043 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.046 | 0.4307 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0114 | 0.1067 | 0.1067 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0204 | 0.0951 |
Echinococcus granulosus | tumor susceptibility gene 101 protein | 0.0084 | 0.0756 | 0.7088 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0204 | 0.1639 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0204 | 0.0411 |
Schistosoma mansoni | kinase | 0.0058 | 0.0488 | 0.4572 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.1067 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.046 | 0.046 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.1067 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0204 | 0.5 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0014 | 0.003 | 0.0283 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 0.1067 | 1 |
Echinococcus multilocularis | tumor susceptibility gene 101 protein | 0.0084 | 0.0756 | 0.0756 |
Schistosoma mansoni | tsg101-related | 0.007 | 0.0611 | 0.5729 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.1067 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.046 | 0.046 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0204 | 0.1639 |
Giardia lamblia | Kinase, PLK | 0.0114 | 0.1067 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0041 | 0.0312 | 0.2685 |
Brugia malayi | hypothetical protein | 0.003 | 0.0204 | 0.0951 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.046 | 0.2147 |
Brugia malayi | N-terminal motif family protein | 0.0218 | 0.214 | 1 |
Mycobacterium tuberculosis | UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) | 0.0688 | 0.6992 | 0.5 |
Trypanosoma brucei | Vps23 core domain containing protein, putative | 0.0027 | 0.0167 | 0.1281 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.046 | 0.4307 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0204 | 0.1639 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0056 | 0.0472 | 0.4241 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0204 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.1067 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0114 | 0.1067 | 0.4986 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0114 | 0.1067 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 0.1067 | 0.4986 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.046 | 0.2147 |
Schistosoma mansoni | tsg101-related | 0.007 | 0.0611 | 0.5729 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.046 | 0.4307 |
Trypanosoma cruzi | Vps23 core domain containing protein, putative | 0.0027 | 0.0167 | 0.1281 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.1067 | 1 |
Mycobacterium leprae | Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) | 0.0688 | 0.6992 | 0.5 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0114 | 0.1067 | 0.4986 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (binding) | = 5.84 uM | PUBCHEM_BIOASSAY: Inhibitors of Mycobacterium tuberculosis UDP-galactopyranose mutase (UGM) enzyme Measured in Biochemical System Using Plate Reader - 2105-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504439] | ChEMBL. | No reference |
Potency (functional) | 0.0015 uM | PubChem BioAssay. qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101: Hit Validation in TR assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.5918 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.3119 uM | PubChem BioAssay. qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101: Hit Validation. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.003 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.