Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0113 | 0.3933 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.3329 | 0.3329 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.023 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.678 | 0.678 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.678 | 0.678 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0105 | 0.345 | 0.345 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.678 | 0.678 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.655 | 0.655 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0209 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.973 | 0.973 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.0113 | 0.3933 | 0.5 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0209 | 1 | 0.5 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.0113 | 0.3933 | 0.3933 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.655 | 0.655 |
Brugia malayi | Serine carboxypeptidase F41C3.5 precursor | 0.0113 | 0.3933 | 0.3933 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.023 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 1 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0113 | 0.3933 | 0.5 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0209 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.678 | 0.678 |
Echinococcus granulosus | geminin | 0.0205 | 0.973 | 0.9601 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0154 | 0.655 | 0.655 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.3933 | 0.3933 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.655 | 0.655 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0105 | 0.345 | 0.345 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0113 | 0.3933 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0105 | 0.345 | 0.345 |
Schistosoma mansoni | neprilysin | 0.0055 | 0.023 | 0.023 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0113 | 0.3933 | 0.5 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0209 | 1 | 1 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0105 | 0.345 | 0.345 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.678 | 0.678 |
Toxoplasma gondii | peptidase family M13 protein | 0.0209 | 1 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0154 | 0.655 | 0.655 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.0113 | 0.3933 | 0.3933 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0105 | 0.345 | 0.345 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.0113 | 0.3933 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.973 | 0.973 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0113 | 0.3933 | 0.5 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0113 | 0.3933 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.023 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.655 | 0.655 |
Echinococcus granulosus | lysosomal protective protein | 0.0113 | 0.3933 | 0.1044 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.023 | 0.023 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0113 | 0.3933 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0055 | 0.023 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 1 | 1 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0209 | 1 | 0.5 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0209 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.023 | 0.023 |
Echinococcus multilocularis | lysosomal protective protein | 0.0113 | 0.3933 | 0.1044 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.678 | 0.678 |
Echinococcus multilocularis | geminin | 0.0205 | 0.973 | 0.9601 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.023 | 0.023 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.6513 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.