Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma brucei | hexokinase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.4207 | 0.4207 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0471 | 1 | 1 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0471 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.0096 | 0.0753 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.0096 | 0.0753 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.0096 | 0.0753 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0096 | 0.0753 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0096 | 0.0753 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.0753 | 0.0753 |
Onchocerca volvulus | 0.0096 | 0.0753 | 0.5 | |
Onchocerca volvulus | 0.0096 | 0.0753 | 0.5 | |
Plasmodium falciparum | hexokinase | 0.0096 | 0.0753 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0096 | 0.0753 | 0.5 |
Toxoplasma gondii | hexokinase | 0.0096 | 0.0753 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.0096 | 0.0753 | 0.0753 |
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 0.0753 | 0.5 |
Onchocerca volvulus | 0.0096 | 0.0753 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.361 | 0.361 |
Brugia malayi | Hexokinase family protein | 0.0096 | 0.0753 | 0.5 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0449 | 0.9434 | 0.9388 |
Treponema pallidum | hexokinase (hxk) | 0.0096 | 0.0753 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 0.0753 | 0.5 |
Leishmania major | hexokinase, putative | 0.0096 | 0.0753 | 0.5 |
Plasmodium vivax | hexokinase, putative | 0.0096 | 0.0753 | 0.5 |
Brugia malayi | hexokinase | 0.0096 | 0.0753 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0471 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.0753 | 0.0753 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 7.291333333 uM | PUBCHEM_BIOASSAY: Confirmation assay for inhibitors of Trypanosoma brucei hexokinase 1-Analogue-first series. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1430, AID1632, AID2516, AID2560, AID2579, AID2600, AID449725, AID492951] | ChEMBL. | No reference |
IC50 (functional) | 25 uM | PUBCHEM_BIOASSAY: G6DPH counterscreen for TbHK1 inhibitors - Analogues series. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1430, AID1632, AID2230, AID2600, AID449725, AID492951] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.