Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | K(lysine) acetyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | GH02984p | 0.227 | 0.2512 | 1 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.227 | 0.2512 | 0.2402 |
Loa Loa (eye worm) | hypothetical protein | 0.227 | 0.2512 | 1 |
Onchocerca volvulus | 0.227 | 0.2512 | 0.5 | |
Schistosoma mansoni | high-affinity choline transporter | 0.227 | 0.2512 | 0.2402 |
Brugia malayi | Sodium:solute symporter family protein | 0.227 | 0.2512 | 1 |
Schistosoma mansoni | inositol transporter | 0.8895 | 1 | 1 |
Schistosoma mansoni | inositol transporter | 0.8895 | 1 | 1 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.8895 | 1 | 1 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.227 | 0.2512 | 0.2508 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.8895 | 1 | 1 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.227 | 0.2512 | 0.2402 |
Echinococcus granulosus | solute carrier family 5 | 0.8895 | 1 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0047 | 0 | 0.5 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0051 | 0.0005 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.0139 | 0.0134 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0051 | 0.0005 | 0.5 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.8895 | 1 | 1 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.8895 | 1 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0047 | 0 | 0.5 |
Echinococcus multilocularis | solute carrier family 5 | 0.8895 | 1 | 1 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.227 | 0.2512 | 1 |
Schistosoma mansoni | sodium/solute symporter | 0.227 | 0.2512 | 0.2402 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0047 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.227 | 0.2512 | 1 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.227 | 0.2512 | 0.2508 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0051 | 0.0005 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.9811 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.