Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0192 | 1 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0065 | 0.2622 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0192 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.103 | 0.103 |
Toxoplasma gondii | thioredoxin reductase | 0.0065 | 0.2622 | 1 |
Onchocerca volvulus | 0.0192 | 1 | 1 | |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3269 | 0.3269 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3269 | 0.3269 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0082 | 0.3608 | 0.3608 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0038 | 0.103 | 0.315 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0065 | 0.2622 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0027 | 0.0409 | 0.1251 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0023 | 0.013 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0038 | 0.103 | 0.315 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.103 | 0.103 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.9188 | 0.9188 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3269 | 0.3269 |
Plasmodium falciparum | thioredoxin reductase | 0.0065 | 0.2622 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0023 | 0.013 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.012 | 0.583 | 0.583 |
Trypanosoma brucei | trypanothione reductase | 0.0065 | 0.2622 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3269 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0023 | 0.013 | 0.013 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0065 | 0.2622 | 0.802 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0023 | 0.013 | 0.0396 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3269 | 0.3269 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0023 | 0.013 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.103 | 0.103 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0023 | 0.013 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0038 | 0.103 | 0.103 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.103 | 0.103 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0027 | 0.0409 | 0.1251 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.012 | 0.583 | 0.583 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3269 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0065 | 0.2622 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3269 | 0.3269 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.3608 | 0.3608 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3269 | 0.3269 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3269 | 0.3269 |
Leishmania major | trypanothione reductase | 0.0065 | 0.2622 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 1 | 1 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0023 | 0.013 | 0.0396 |
Loa Loa (eye worm) | glutathione reductase | 0.0065 | 0.2622 | 0.2622 |
Onchocerca volvulus | 0.0192 | 1 | 1 | |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0065 | 0.2622 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3269 | 0.3269 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0023 | 0.013 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.583 | 0.583 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.103 | 0.103 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0023 | 0.013 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0038 | 0.103 | 0.315 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0027 | 0.0409 | 0.1251 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0065 | 0.2622 | 0.2622 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0038 | 0.103 | 0.103 |
Brugia malayi | glutathione reductase | 0.0065 | 0.2622 | 0.2622 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.3608 | 0.3608 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0065 | 0.2622 | 0.802 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0023 | 0.013 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3269 | 0.3269 |
Onchocerca volvulus | 0.0192 | 1 | 1 | |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3269 | 0.3269 |
Echinococcus granulosus | GPCR family 2 | 0.0038 | 0.103 | 0.315 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3269 | 0.3269 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.012 | 0.583 | 0.583 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0023 | 0.013 | 0.013 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0038 | 0.103 | 0.103 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0065 | 0.2622 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0023 | 0.013 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0038 | 0.103 | 0.315 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0023 | 0.013 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0065 | 0.2622 | 0.2622 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0023 | 0.013 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0023 | 0.013 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0038 | 0.103 | 0.315 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.9953 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 32.6294 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.