Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | beta-site APP-cleaving enzyme 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K07747 beta-site APP-cleaving enzyme 2 (memapsin 1) [EC3.4.23.45], putative | Get druggable targets OG5_135830 | All targets in OG5_135830 |
Schistosoma mansoni | memapsin-2 (A01 family) | Get druggable targets OG5_135830 | All targets in OG5_135830 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | plasmepsin VII | beta-site APP-cleaving enzyme 1 | 401 aa | 352 aa | 21.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | carnitine palmitoyltransferase-like protein | 0.1108 | 0.1233 | 0.2328 |
Onchocerca volvulus | 0.062 | 0.0209 | 0.5 | |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.1108 | 0.1233 | 0.2328 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.2714 | 0.461 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.2714 | 0.461 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0635 | 0.0239 | 0.0031 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.1108 | 0.1233 | 0.1047 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.2714 | 0.461 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.2714 | 0.461 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.1108 | 0.1233 | 0.2328 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.1108 | 0.1233 | 0.2328 |
Loa Loa (eye worm) | hypothetical protein | 0.5279 | 1 | 1 |
Onchocerca volvulus | 0.062 | 0.0209 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0635 | 0.0239 | 0.0031 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.2714 | 0.461 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.1108 | 0.1233 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.062 | 0.0209 | 1 |
Onchocerca volvulus | 0.062 | 0.0209 | 0.5 | |
Brugia malayi | NNMT/PNMT/TEMT family protein | 0.0635 | 0.0239 | 0.0031 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.1108 | 0.1233 | 0.1047 |
Schistosoma mansoni | choline o-acyltransferase | 0.062 | 0.0209 | 1 |
Onchocerca volvulus | 0.062 | 0.0209 | 0.5 | |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0635 | 0.0239 | 0.0031 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6 nM | Binding affinity to BACE assessed as displacement of [3H]BMS-599240 | ChEMBL. | 19375914 |
IC50 (binding) | = 184 nM | Inhibition of BACE1 in human HEK293 cells overexpressing APP with Swedish mutation assessed as inhibition of amyloid beta 40 production | ChEMBL. | 19375914 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.