Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0026 | 0.0194 | 0.0887 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0108 | 0.219 | 0.219 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0026 | 0.0194 | 0.0194 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0026 | 0.0194 | 0.0194 |
Echinococcus multilocularis | hypothetical protein | 0.0251 | 0.5682 | 0.5682 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0026 | 0.0194 | 0.0887 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0026 | 0.0194 | 0.0194 |
Toxoplasma gondii | protein kinase G AGC kinase family member PKG | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | dual specificity | 0.0108 | 0.219 | 0.219 |
Brugia malayi | Protein kinase domain containing protein | 0.0108 | 0.219 | 1 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0429 | 1 | 1 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0108 | 0.219 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0026 | 0.0194 | 0.0194 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0026 | 0.0194 | 0.0194 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0026 | 0.0194 | 0.0194 |
Echinococcus granulosus | dual specificity | 0.0108 | 0.219 | 0.219 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.2176 | 0.9938 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0169 | 0.368 | 0.368 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0194 | 0.0887 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0026 | 0.0194 | 0.0194 |
Echinococcus granulosus | voltage gated potassium channel | 0.0026 | 0.0194 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0194 | 0.0887 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0429 | 1 | 1 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0429 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0251 | 0.5682 | 0.5682 |
Plasmodium falciparum | cGMP-dependent protein kinase | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0429 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0026 | 0.0194 | 0.0194 |
Entamoeba histolytica | protein kinase, putative | 0.0108 | 0.219 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0108 | 0.219 | 0.5 |
Echinococcus granulosus | Ion_trans_N domain containing protein | 0.0251 | 0.5682 | 0.5682 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0026 | 0.0194 | 0.0887 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0026 | 0.0194 | 0.0887 |
Entamoeba histolytica | protein kinase, putative | 0.0108 | 0.219 | 0.5 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0026 | 0.0194 | 0.0887 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0429 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0026 | 0.0194 | 0.0194 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0026 | 0.0194 | 0.0194 |
Entamoeba histolytica | hypothetical protein | 0.0108 | 0.219 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0026 | 0.0194 | 0.0194 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0026 | 0.0194 | 0.0194 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0178 | 0.3887 | 1 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0108 | 0.219 | 1 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0026 | 0.0194 | 0.0194 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0429 | 1 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0026 | 0.0194 | 0.0194 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0108 | 0.219 | 0.5 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0026 | 0.0194 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.2176 | 0.9938 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0026 | 0.0194 | 0.0194 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0108 | 0.219 | 0.5 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0429 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0026 | 0.0194 | 0.0887 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0026 | 0.0194 | 0.0194 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0108 | 0.219 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0026 | 0.0194 | 0.0194 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (binding) | = 3.245 uM | PUBCHEM_BIOASSAY: MLPCN Dyrk1A Kinase Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504442] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.