TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 418.485 | Formula: C25H26N2O4
H donors: 2 H acceptors: 2 LogP: 3.97 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(CNC(=O)C(NC(=O)c2ccccc2)Cc2ccccc2)ccc1OC
InChi: 1S/C25H26N2O4/c1-30-22-14-13-19(16-23(22)31-2)17-26-25(29)21(15-18-9-5-3-6-10-18)27-24(28)20-11-7-4-8-12-20/h3-14,16,21H,15,17H2,1-2H3,(H,26,29)(H,27,28)
InChiKey: JTQODLHRQUAQDS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references
Homo sapiens	glycoprotein hormones, alpha polypeptide	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Toxoplasma gondii	intraflagellar transport protein 172, putative	glycoprotein hormones, alpha polypeptide	116 aa	94 aa	26.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0024	0.0686	0.0686
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.2034	0.2034
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.004	0.2034	0.3825
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0024	0.0686	0.0758
Schistosoma mansoni	voltage-gated potassium channel	0.0024	0.0686	0.0686
Echinococcus granulosus	g protein coupled receptor	0.004	0.2034	0.2249
Schistosoma mansoni	biogenic amine receptor	0.004	0.2034	0.2034
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.004	0.2034	0.2034
Brugia malayi	ORL1-like opioid receptor	0.004	0.2034	0.2249
Echinococcus granulosus	tm gpcr rhodopsin	0.004	0.2034	0.2249
Echinococcus multilocularis	serotonin receptor	0.004	0.2034	0.2249
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0023	0.0553	0.5
Loa Loa (eye worm)	hypothetical protein	0.0098	0.6913	0.7645
Echinococcus multilocularis	neuropeptides capa receptor	0.004	0.2034	0.2249
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0024	0.0686	0.0758
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Onchocerca volvulus		0.004	0.2034	0.3825
Loa Loa (eye worm)	G-protein coupled receptor	0.004	0.2034	0.2249
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0553	1
Schistosoma mansoni	histamine h1 receptor	0.004	0.2034	0.2034
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0023	0.0553	0.5
Echinococcus granulosus	neuropeptide receptor	0.004	0.2034	0.2249
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.01	0.7146	0.7903
Schistosoma mansoni	biogenic amine (5HT) receptor	0.004	0.2034	0.2034
Brugia malayi	RE15519p	0.004	0.2034	0.2249
Echinococcus multilocularis	voltage gated potassium channel	0.0036	0.1643	0.1816
Onchocerca volvulus		0.004	0.2034	0.3825
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.2034	0.2034
Brugia malayi	bZIP transcription factor family protein	0.01	0.7146	0.7903
Loa Loa (eye worm)	neuropeptide F receptor	0.004	0.2034	0.2249
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.004	0.2034	0.2034
Echinococcus granulosus	hyperpolarization activated cyclic	0.0024	0.0686	0.0758
Schistosoma mansoni	biogenic amine receptor	0.004	0.2034	0.2034
Echinococcus granulosus	neuropeptides capa receptor	0.004	0.2034	0.2249
Loa Loa (eye worm)	G-protein coupled receptor	0.004	0.2034	0.2249
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.01	0.7146	0.7903
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Schistosoma mansoni	neuropeptide receptor	0.004	0.2034	0.2034
Schistosoma mansoni	neuropeptide receptor	0.004	0.2034	0.2034
Onchocerca volvulus		0.004	0.2034	0.3825
Echinococcus granulosus	hyperpolarization activated cyclic	0.0024	0.0686	0.0758
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.2034	0.2034
Echinococcus multilocularis	g protein coupled receptor	0.004	0.2034	0.2249
Echinococcus multilocularis	allatostatin A receptor	0.004	0.2034	0.2249
Onchocerca volvulus		0.004	0.2034	0.3825
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Echinococcus multilocularis	G protein coupled receptor 139	0.004	0.2034	0.2249
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Brugia malayi	putative neuropeptide receptor NPR1	0.004	0.2034	0.2249
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.004	0.2034	0.2034
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.004	0.2034	0.2249
Onchocerca volvulus		0.004	0.2034	0.3825
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.004	0.2034	0.2034
Onchocerca volvulus		0.004	0.2034	0.3825
Echinococcus granulosus	7TM GPCR rhodopsin	0.004	0.2034	0.2249
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.004	0.2034	0.2249
Brugia malayi	neuropeptide F receptor	0.004	0.2034	0.2249
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Echinococcus multilocularis	dro:myosuppressin receptor	0.004	0.2034	0.2249
Brugia malayi	GnHR receptor homolog	0.004	0.2034	0.2249
Onchocerca volvulus	Neuropeptide F receptor homolog	0.004	0.2034	0.3825
Brugia malayi	neuropeptide F receptor	0.004	0.2034	0.2249
Loa Loa (eye worm)	melatonin receptor type 1A	0.004	0.2034	0.2249
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.2034	0.2249
Schistosoma mansoni	myosin xvIII	0.004	0.2034	0.2034
Echinococcus granulosus	hypothetical protein	0.004	0.2034	0.2249
Brugia malayi	Serotonin receptor	0.004	0.2034	0.2249
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0023	0.0553	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Brugia malayi	G-protein coupled receptor	0.004	0.2034	0.2249
Onchocerca volvulus		0.004	0.2034	0.3825
Echinococcus granulosus	alpha 1A adrenergic receptor	0.004	0.2034	0.2249
Onchocerca volvulus		0.004	0.2034	0.3825
Schistosoma mansoni	voltage-gated potassium channel	0.0019	0.0267	0.0267
Toxoplasma gondii	exonuclease III APE	0.0023	0.0553	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.2034	0.2034
Schistosoma mansoni	amine GPCR	0.004	0.2034	0.2034
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.004	0.2034	0.2034
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.004	0.2034	0.2249
Onchocerca volvulus		0.004	0.2034	0.3825
Brugia malayi	Dopamine receptor	0.004	0.2034	0.2249
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.004	0.2034	0.2249
Echinococcus multilocularis	neuropeptide receptor	0.004	0.2034	0.2249
Onchocerca volvulus		0.004	0.2034	0.3825
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.004	0.2034	0.2249
Onchocerca volvulus		0.004	0.2034	0.3825
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0024	0.0686	0.0758
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Brugia malayi	hypothetical protein	0.004	0.2034	0.2249
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0024	0.0686	0.0758
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0023	0.0553	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.004	0.2034	0.2249
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.004	0.2034	0.2249
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.004	0.2034	0.2249
Echinococcus multilocularis	serotonin receptor	0.004	0.2034	0.2249
Schistosoma mansoni	amine GPCR	0.004	0.2034	0.2034
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.2034	0.2249
Echinococcus granulosus	allatostatin A receptor	0.004	0.2034	0.2249
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.004	0.2034	0.2249
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.004	0.2034	0.2249
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0024	0.0686	0.0758
Schistosoma mansoni	neuropeptide receptor	0.004	0.2034	0.2034
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0024	0.0686	0.0758
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0024	0.0686	0.0686
Schistosoma mansoni	amine GPCR	0.004	0.2034	0.2034
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.004	0.2034	0.2249
Echinococcus multilocularis	fmrfamide receptor	0.004	0.2034	0.2249
Brugia malayi	Melatonin receptor type 1A	0.004	0.2034	0.2249
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.0553	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1643	0.1816
Echinococcus granulosus	neuropeptide receptor	0.004	0.2034	0.2249
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0553	1
Brugia malayi	larval opioid receptor	0.004	0.2034	0.2249
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.004	0.2034	0.2034
Schistosoma mansoni	alpha-1 adrenergic receptor	0.004	0.2034	0.2034
Schistosoma mansoni	voltage-gated potassium channel	0.0134	1	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.004	0.2034	0.2249
Echinococcus granulosus	G protein coupled receptor 139	0.004	0.2034	0.2249
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0023	0.0553	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Schistosoma mansoni	biogenic amine (5HT) receptor	0.004	0.2034	0.2034
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Brugia malayi	hypothetical protein	0.0079	0.5316	0.5879
Echinococcus multilocularis	jun protein	0.01	0.7146	0.7903
Echinococcus granulosus	sex peptide receptor	0.004	0.2034	0.2249
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.004	0.2034	0.2249
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.004	0.2034	0.2249
Schistosoma mansoni	voltage-gated potassium channel	0.0036	0.1643	0.1643
Echinococcus multilocularis	g-protein coupled receptor	0.004	0.2034	0.2249
Brugia malayi	Serotonin receptor	0.004	0.2034	0.2249
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.2034	0.2249
Brugia malayi	Dopamine receptor protein 1	0.004	0.2034	0.2249
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.004	0.2034	0.2034
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.2034	0.2034
Schistosoma mansoni	hypothetical protein	0.004	0.2034	0.2034
Brugia malayi	hypothetical protein	0.004	0.2034	0.2249
Brugia malayi	hypothetical protein	0.004	0.2034	0.2249
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.004	0.2034	0.2249
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.004	0.2034	0.2249
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0024	0.0686	0.082
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0553	0.0662
Schistosoma mansoni	opsin-like receptor	0.004	0.2034	0.2034
Brugia malayi	sulfakinin receptor protein	0.004	0.2034	0.2249
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0686	0.0758
Brugia malayi	Dopamine receptor protein 2	0.004	0.2034	0.2249
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0036	0.1643	0.1816
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0036	0.1643	0.1816
Echinococcus multilocularis	G-protein coupled receptor, putative	0.004	0.2034	0.2249
Onchocerca volvulus		0.004	0.2034	0.3825
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.2034	0.2249
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.004	0.2034	0.2034
Echinococcus granulosus	tachykinin peptides receptor 99D	0.004	0.2034	0.2249
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.004	0.2034	0.2249
Schistosoma mansoni	amine GPCR	0.004	0.2034	0.2034
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.2034	0.2249
Echinococcus granulosus	neuropeptides capa receptor	0.004	0.2034	0.2249
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0553	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.2034	0.2249
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.2034	0.2034
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.004	0.2034	0.2034
Brugia malayi	G-protein coupled receptor	0.004	0.2034	0.2249
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.2034	0.2249
Echinococcus multilocularis	neuropeptides capa receptor	0.004	0.2034	0.2249
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.0553	0.0612
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.2034	0.2249
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.004	0.2034	0.2249
Mycobacterium leprae	Conserved hypothetical protein	0.0016	0	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.004	0.2034	0.2249
Echinococcus multilocularis	orexin receptor type 2	0.004	0.2034	0.2249
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.2034	0.2249
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0553	0.0662
Echinococcus multilocularis	neuropeptide receptor A26	0.004	0.2034	0.2249
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.004	0.2034	0.2249
Echinococcus granulosus	g protein coupled receptor	0.004	0.2034	0.2249
Echinococcus multilocularis	fmrfamide receptor	0.004	0.2034	0.2249
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0024	0.0686	0.0758
Onchocerca volvulus		0.004	0.2034	0.3825
Brugia malayi	putative neuropeptide receptor	0.004	0.2034	0.2249
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Echinococcus granulosus	neuropeptide receptor A26	0.004	0.2034	0.2249
Brugia malayi	AKH receptor	0.004	0.2034	0.2249
Echinococcus multilocularis	neuropeptide FF receptor 2	0.004	0.2034	0.2249
Echinococcus multilocularis	g protein coupled receptor	0.004	0.2034	0.2249
Echinococcus multilocularis	neuropeptide Y receptor	0.004	0.2034	0.2249
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0024	0.0686	0.0758
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Schistosoma mansoni	adenoreceptor	0.004	0.2034	0.2034
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.2034	0.2249
Echinococcus multilocularis	neuropeptide receptor	0.004	0.2034	0.2249
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.2034	0.2249
Schistosoma mansoni	ap endonuclease	0.0023	0.0553	0.0553
Onchocerca volvulus		0.004	0.2034	0.3825
Schistosoma mansoni	neuropeptide receptor	0.004	0.2034	0.2034
Echinococcus granulosus	neuropeptide Y receptor	0.004	0.2034	0.2249
Brugia malayi	hypothetical protein	0.004	0.2034	0.2249
Brugia malayi	G protein-coupled receptor	0.004	0.2034	0.2249
Brugia malayi	hypothetical protein	0.004	0.2034	0.2249
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0115	0.8357	1
Onchocerca volvulus		0.0079	0.5316	1
Brugia malayi	hypothetical protein	0.004	0.2034	0.2249
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0023	0.0553	1
Echinococcus granulosus	g-protein coupled receptor	0.004	0.2034	0.2249
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.004	0.2034	0.2249
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.004	0.2034	0.2249
Schistosoma mansoni	opsin-like receptor	0.004	0.2034	0.2034
Onchocerca volvulus		0.004	0.2034	0.3825
Loa Loa (eye worm)	TYRA-2 protein	0.004	0.2034	0.2249
Schistosoma mansoni	hypothetical protein	0.004	0.2034	0.2034
Schistosoma mansoni	ap endonuclease	0.0023	0.0553	0.0553
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.004	0.2034	0.2249
Brugia malayi	G protein-coupled receptor F59B2.13	0.004	0.2034	0.2249
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Schistosoma mansoni	jun-related protein	0.0082	0.555	0.555
Echinococcus granulosus	voltage gated potassium channel	0.0036	0.1643	0.1816
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Echinococcus multilocularis	sex peptide receptor	0.004	0.2034	0.2249
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.2034	0.2249
Schistosoma mansoni	biogenic amine receptor	0.004	0.2034	0.2034
Echinococcus granulosus	tm gpcr rhodopsin	0.004	0.2034	0.2249
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0023	0.0553	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.004	0.2034	0.2034
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.004	0.2034	0.2249
Schistosoma mansoni	neuropeptide F-like receptor	0.004	0.2034	0.2034
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.2034	0.2249
Echinococcus granulosus	peptide allatostatin:somatostatin	0.004	0.2034	0.2249
Brugia malayi	hypothetical protein	0.004	0.2034	0.2249
Schistosoma mansoni	amine GPCR	0.004	0.2034	0.2034
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0024	0.0686	0.082
Onchocerca volvulus		0.004	0.2034	0.3825
Echinococcus multilocularis	neuropeptide s receptor	0.004	0.2034	0.2249
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.2034	0.2249
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.004	0.2034	0.2249
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0115	0.8357	1
Schistosoma mansoni	60S ribosomal protein L21	0.0019	0.0267	0.0267
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0024	0.0686	0.0686
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.004	0.2034	0.2249
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Echinococcus granulosus	neuropeptide FF receptor 2	0.004	0.2034	0.2249
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.004	0.2034	0.2249
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.2034	0.2034
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.2034	0.2034
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Echinococcus multilocularis	somatostatin receptor	0.004	0.2034	0.2249
Brugia malayi	hypothetical protein	0.004	0.2034	0.2249
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.004	0.2034	0.2249
Echinococcus multilocularis	g protein coupled receptor	0.004	0.2034	0.2249
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.2034	0.2249
Loa Loa (eye worm)	neuropeptide F receptor	0.004	0.2034	0.2249
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0024	0.0686	0.0758
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Echinococcus granulosus	tm gpcr rhodopsin	0.004	0.2034	0.2249
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0036	0.1643	0.1816
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Echinococcus granulosus	g protein coupled receptor	0.004	0.2034	0.2249
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.004	0.2034	0.2249
Schistosoma mansoni	hypothetical protein	0.004	0.2034	0.2034
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0553	1
Schistosoma mansoni	neuropeptide F-like receptor	0.004	0.2034	0.2034
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.004	0.2034	0.2034
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Schistosoma mansoni	hypothetical protein	0.004	0.2034	0.2034
Brugia malayi	follicle stimulating hormone receptor	0.004	0.2034	0.2249
Brugia malayi	hypothetical protein	0.004	0.2034	0.2249
Echinococcus granulosus	fmrfamide receptor	0.004	0.2034	0.2249
Echinococcus granulosus	7tm_1 domain containing protein	0.004	0.2034	0.2249
Echinococcus granulosus	dro:myosuppressin receptor	0.004	0.2034	0.2249
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.0553	0.0612
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0024	0.0686	0.0758
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0024	0.0686	0.0686
Brugia malayi	Tachykinin-like peptides receptor 99D	0.004	0.2034	0.2249
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.0553	0.0612
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.004	0.2034	0.2249
Schistosoma mansoni	neuropeptide f receptor 76f	0.004	0.2034	0.2034
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.004	0.2034	0.2249
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.2034	0.2034
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0024	0.0686	0.0686
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.004	0.2034	0.2034
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.0553	0.0612
Schistosoma mansoni	voltage-gated potassium channel	0.0036	0.1643	0.1643
Brugia malayi	hypothetical protein	0.004	0.2034	0.2249
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0123	0.9043	1
Echinococcus granulosus	somatostatin receptor	0.004	0.2034	0.2249
Schistosoma mansoni	opsin-like receptor	0.004	0.2034	0.2034
Loa Loa (eye worm)	hypothetical protein	0.0106	0.7667	0.8478
Echinococcus granulosus	serotonin receptor	0.004	0.2034	0.2249
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0123	0.9043	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.004	0.2034	0.2034
Schistosoma mansoni	hypothetical protein	0.0082	0.555	0.555
Echinococcus granulosus	neuropeptide Y receptor	0.004	0.2034	0.2249
Onchocerca volvulus		0.004	0.2034	0.3825
Echinococcus granulosus	jun protein	0.01	0.7146	0.7903
Echinococcus granulosus	orexin receptor type 2	0.004	0.2034	0.2249
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0024	0.0686	0.0758
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0024	0.0686	0.0758
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Echinococcus granulosus	neuropeptide s receptor	0.004	0.2034	0.2249
Echinococcus multilocularis	neuropeptide Y receptor	0.004	0.2034	0.2249
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0123	0.9043	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Chlamydia trachomatis	cAMP-dependent protein kinase regulatory subunit	0.0016	0	0.5
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0123	0.9043	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Loa Loa (eye worm)	hypothetical protein	0.004	0.2034	0.2249
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.004	0.2034	0.2249
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.004	0.2034	0.2034

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.6702 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.8913 uM	PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1892141

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1536354