Detailed information for compound 1536625

Basic information

Technical information
  • TDR Targets ID: 1536625
  • Name: N-(5-chloro-2-morpholin-4-ylphenyl)-3-methylb enzenesulfonamide
  • MW: 366.862 | Formula: C17H19ClN2O3S
  • H donors: 1 H acceptors: 2 LogP: 3.19 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)NS(=O)(=O)c1cccc(c1)C)N1CCOCC1
  • InChi: 1S/C17H19ClN2O3S/c1-13-3-2-4-15(11-13)24(21,22)19-16-12-14(18)5-6-17(16)20-7-9-23-10-8-20/h2-6,11-12,19H,7-10H2,1H3
  • InChiKey: PHEVNWXLHNNLEO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(5-chloro-2-morpholino-phenyl)-3-methyl-benzenesulfonamide
  • N-(5-chloro-2-morpholinophenyl)-3-methylbenzenesulfonamide
  • N-(5-chloro-2-morpholin-4-yl-phenyl)-3-methyl-benzenesulfonamide
  • ZINC02657217

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0383 0.4255 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0422 0.0993
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0383 0.4255 0.4796
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0422 0.0993
Loa Loa (eye worm) DOMON domain-containing protein 0.0073 0.0077 0.018
Trichomonas vaginalis DNA-3-methyladenine glycosylase, putative 0.0187 0.1616 0.5
Loa Loa (eye worm) DOMON domain-containing protein 0.0073 0.0077 0.018
Brugia malayi DOMON domain containing protein 0.0073 0.0077 0.018
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0383 0.4255 1
Loa Loa (eye worm) hypothetical protein 0.0383 0.4255 1
Mycobacterium leprae PROBABLE DNA-3-METHYLADENINE GLYCOSYLASE I TAGA (TAG I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine g 0.0093 0.0342 0.5
Mycobacterium tuberculosis Probable DNA-3-methyladenine glycosylase I TagA (tag I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine g 0.0093 0.0342 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0422 0.0993
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0194 0.171 0.4018
Trichomonas vaginalis DNA-3-methyladenine glycosylase, putative 0.0187 0.1616 0.5
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0189 0.1633 0.3837
Schistosoma mansoni dopamine-beta-monooxygenase 0.0725 0.8871 1
Brugia malayi DOMON domain containing protein 0.0073 0.0077 0.018
Schistosoma mansoni peptidylglycine monooxygenase 0.0383 0.4255 0.4796
Onchocerca volvulus 0.0073 0.0077 0.5
Mycobacterium ulcerans DNA-3-methyladenine glycosylase I TagA 0.0187 0.1616 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0422 0.0993
Brugia malayi DOMON domain containing protein 0.0073 0.0077 0.018
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0383 0.4255 1
Loa Loa (eye worm) DOMON domain-containing protein 0.0073 0.0077 0.018
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0383 0.4255 0.5
Onchocerca volvulus 0.0073 0.0077 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.