Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0315 | 0.3033 | 0.3033 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0315 | 0.3033 | 0.3033 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0823 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0823 | 1 | 1 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0315 | 0.3033 | 0.3033 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0823 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.3093 | 0.3093 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0315 | 0.3033 | 0.3033 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0315 | 0.3033 | 0.3033 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0215 | 0.1665 | 0.1665 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0408 | 0.4316 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0315 | 0.3033 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0508 | 0.5684 | 0.5684 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0823 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0508 | 0.5684 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0823 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0823 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0315 | 0.3033 | 0.3033 |
Loa Loa (eye worm) | hypothetical protein | 0.0823 | 1 | 1 |
Echinococcus multilocularis | methionine synthase reductase | 0.0508 | 0.5684 | 0.5684 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0823 | 1 | 1 |
Onchocerca volvulus | 0.0094 | 0 | 0.5 | |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0197 | 0.1417 | 0.1417 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0319 | 0.3093 | 0.3093 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0823 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0094 | 0 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0823 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0729 | 0.8717 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0823 | 1 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0197 | 0.1417 | 0.1417 |
Mycobacterium tuberculosis | Hypothetical oxidoreductase | 0.0094 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.3093 | 0.3093 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0508 | 0.5684 | 0.5684 |
Brugia malayi | FAD binding domain containing protein | 0.0508 | 0.5684 | 0.5684 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.1061 | 0.1061 |
Giardia lamblia | Hypothetical protein | 0.0729 | 0.8717 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0823 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0823 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0823 | 1 | 1 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0315 | 0.3033 | 0.2047 |
Plasmodium vivax | hypothetical protein, conserved | 0.0315 | 0.3033 | 0.3033 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0823 | 1 | 1 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0315 | 0.3033 | 0.2047 |
Treponema pallidum | flavodoxin | 0.0315 | 0.3033 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0215 | 0.1665 | 0.1665 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0823 | 1 | 1 |
Brugia malayi | flavodoxin family protein | 0.0315 | 0.3033 | 0.3033 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0094 | 0 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0823 | 1 | 1 |
Mycobacterium tuberculosis | Probable monooxygenase | 0.0094 | 0 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0315 | 0.3033 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0315 | 0.3033 | 0.5 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0315 | 0.3033 | 0.2047 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0823 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0823 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0415 | 0.4402 | 0.4402 |
Echinococcus granulosus | methionine synthase reductase | 0.0508 | 0.5684 | 0.5684 |
Loa Loa (eye worm) | hypothetical protein | 0.0439 | 0.4737 | 0.4737 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0197 | 0.1417 | 0.1417 |
Leishmania major | p450 reductase, putative | 0.0823 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0823 | 1 | 1 |
Schistosoma mansoni | amine GPCR | 0.0355 | 0.3586 | 0.3586 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0319 | 0.3093 | 0.3093 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0315 | 0.3033 | 0.3033 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0197 | 0.1417 | 0.1417 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0408 | 0.4316 | 1 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0315 | 0.3033 | 0.2047 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0315 | 0.3033 | 0.5 |
Mycobacterium tuberculosis | Possible oxygenase | 0.0094 | 0 | 0.5 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0729 | 0.8717 | 0.8536 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0408 | 0.4316 | 0.4316 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0729 | 0.8717 | 0.8717 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0315 | 0.3033 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0439 | 0.4737 | 0.4737 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0823 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0729 | 0.8717 | 0.8717 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0315 | 0.3033 | 0.3033 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.