Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | FAD binding domain containing protein | 0.0508 | 0.5684 | 0.5684 |
Mycobacterium tuberculosis | Possible oxygenase | 0.0094 | 0 | 0.5 |
Onchocerca volvulus | 0.0094 | 0 | 0.5 | |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0823 | 1 | 1 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0315 | 0.3033 | 0.3033 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0315 | 0.3033 | 0.5 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0315 | 0.3033 | 0.2047 |
Mycobacterium tuberculosis | Hypothetical oxidoreductase | 0.0094 | 0 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0823 | 1 | 1 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0408 | 0.4316 | 0.4316 |
Trypanosoma cruzi | p450 reductase, putative | 0.0823 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0823 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0823 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0823 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0823 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0315 | 0.3033 | 0.3033 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0197 | 0.1417 | 0.1417 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0508 | 0.5684 | 0.5684 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0729 | 0.8717 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0215 | 0.1665 | 0.1665 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0823 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0823 | 1 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0197 | 0.1417 | 0.1417 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0823 | 1 | 1 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0315 | 0.3033 | 0.2047 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0094 | 0 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0823 | 1 | 1 |
Brugia malayi | flavodoxin family protein | 0.0315 | 0.3033 | 0.3033 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0823 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0408 | 0.4316 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0415 | 0.4402 | 0.4402 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0197 | 0.1417 | 0.1417 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0823 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0823 | 1 | 1 |
Mycobacterium tuberculosis | Probable monooxygenase | 0.0094 | 0 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0823 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0729 | 0.8717 | 0.8717 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0823 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0508 | 0.5684 | 0.5684 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0823 | 1 | 1 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0319 | 0.3093 | 0.3093 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0315 | 0.3033 | 0.5 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0319 | 0.3093 | 0.3093 |
Chlamydia trachomatis | sulfite reductase | 0.0508 | 0.5684 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0215 | 0.1665 | 0.1665 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0823 | 1 | 1 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0315 | 0.3033 | 0.3033 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.3093 | 0.3093 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0408 | 0.4316 | 1 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0315 | 0.3033 | 0.2047 |
Loa Loa (eye worm) | hypothetical protein | 0.0823 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0315 | 0.3033 | 0.5 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0315 | 0.3033 | 0.3033 |
Leishmania major | hypothetical protein, conserved | 0.0315 | 0.3033 | 0.3033 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0094 | 0 | 0.5 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0315 | 0.3033 | 0.3033 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.3093 | 0.3093 |
Echinococcus granulosus | methionine synthase reductase | 0.0508 | 0.5684 | 0.5684 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0823 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0439 | 0.4737 | 0.4737 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0315 | 0.3033 | 0.3033 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0729 | 0.8717 | 0.8536 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0315 | 0.3033 | 0.5 |
Echinococcus multilocularis | methionine synthase reductase | 0.0508 | 0.5684 | 0.5684 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0315 | 0.3033 | 0.3033 |
Loa Loa (eye worm) | hypothetical protein | 0.0439 | 0.4737 | 0.4737 |
Treponema pallidum | flavodoxin | 0.0315 | 0.3033 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0823 | 1 | 1 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0315 | 0.3033 | 0.3033 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.1061 | 0.1061 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0197 | 0.1417 | 0.1417 |
Giardia lamblia | Hypothetical protein | 0.0729 | 0.8717 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0823 | 1 | 1 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0315 | 0.3033 | 0.2047 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0315 | 0.3033 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0355 | 0.3586 | 0.3586 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0729 | 0.8717 | 0.8717 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.