Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3514 | 0.3514 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3514 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2517 | 0.2517 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3514 | 0.3514 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3514 | 0.3514 |
Onchocerca volvulus | 0.0182 | 1 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3514 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1351 | 0.1351 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3514 | 0.3514 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3514 | 0.3514 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3514 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2517 | 0.2517 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1351 | 0.1351 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1351 | 0.3844 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2517 | 0.2517 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3514 | 0.3514 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3514 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2517 | 0.2517 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3514 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3514 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3514 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0019 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 89.216 uM | PUBCHEM_BIOASSAY: Luminescence-based cell-based high throughput dose response assay for biased ligands (agonists) of the melanocortin 4 receptor (MC4R). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.