Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.2554 | 0.4571 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2554 | 0.2554 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0333 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.0333 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0.0333 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.1889 | 0.3381 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.0333 | 0.0333 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.0333 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0333 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.2554 | 0.4571 |
Brugia malayi | RNA binding protein | 0.0065 | 0.2554 | 0.4571 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.1014 | 0.1816 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.2554 | 0.4571 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.0333 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1014 | 0.1816 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2554 | 0.2554 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.2554 | 0.2554 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0333 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0333 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.2554 | 0.4571 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.2554 | 0.2554 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2554 | 0.2554 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2554 | 0.2554 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.5586 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.5586 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0333 | 0.0333 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0333 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1014 | 0.1014 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0333 | 0.0596 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.0333 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.0333 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.1889 | 0.3381 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1889 | 0.3381 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0.0333 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0333 | 0.0333 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.1889 | 0.3381 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2554 | 0.2554 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.0333 | 0.0333 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0333 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.2554 | 0.4571 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0.0333 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0333 | 0.0596 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.5586 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0333 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0024 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.0041 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): Confirmation of Cherrypicks. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 52.1194 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.