Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear receptor subfamily 2, group F, member 1 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Herpes simplex virus (type 1 / strain 17) | Alpha trans-inducing protein (VP16) | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | nuclear receptor subfamily 2, group F, member 1 | 423 aa | 354 aa | 26.3 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0038 | 0.0089 | 0.152 |
Brugia malayi | hypothetical protein | 0.003 | 0.0053 | 0.0908 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0089 | 0.3008 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0038 | 0.0089 | 0.1871 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0121 | 0.0473 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0053 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0082 | 0.0294 | 0.5054 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0089 | 0.3008 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0294 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0038 | 0.0089 | 0.1871 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.0582 | 0.0582 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.012 | 0.0472 | 0.0472 |
Echinococcus granulosus | GPCR family 2 | 0.0038 | 0.0089 | 0.1871 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0038 | 0.0089 | 0.152 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.012 | 0.0472 | 0.81 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0053 | 0.0053 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0121 | 0.0473 | 1 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.2168 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2168 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.0582 | 0.0582 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0472 | 0.0472 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0121 | 0.0473 | 0.8127 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0446 | 0.0446 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0114 | 0.0443 | 0.0443 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0089 | 0.3008 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0053 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0019 | 0 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0053 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.0582 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.012 | 0.0472 | 0.81 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0038 | 0.0089 | 0.0089 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0053 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0294 | 0.0294 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0089 | 0.3008 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0053 | 1 |
Toxoplasma gondii | hypothetical protein | 0.2168 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2168 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0053 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0053 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0038 | 0.0089 | 0.1871 |
Echinococcus multilocularis | GPCR, family 2 | 0.0038 | 0.0089 | 0.1871 |
Brugia malayi | hypothetical protein | 0.002 | 0.0003 | 0.0046 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0053 | 0.0053 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0038 | 0.0089 | 0.1871 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0089 | 0.0089 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 6.399 uM | PubChem BioAssay. Luminescence-based cell-based high throughput dose response assay to identify inhibitors of COUP-TFII (NR2F2). (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | 12.74 uM | PubChem BioAssay. Counterscreen for inhibitors of COUP-TFII (NR2F2): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.9093 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.