Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0042 | 0.0065 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0163 | 0.8222 | 1 |
Onchocerca volvulus | 0.011 | 0.4617 | 0.5 | |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0042 | 0.0065 | 0.0065 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0609 | 0.0741 |
Trypanosoma brucei | glucosidase, putative | 0.0042 | 0.0065 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0042 | 0.0065 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.019 | 1 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.019 | 1 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0042 | 0.0065 | 0.5 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0042 | 0.0065 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0042 | 0.0065 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0042 | 0.0065 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.0065 | 0.5 |
Brugia malayi | Hypothetical WD-repeat protein F35G12.4 in chromosome III | 0.0117 | 0.5088 | 0.5088 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.019 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0163 | 0.8222 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.019 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0067 | 0.1711 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1281 | 0.1281 |
Echinococcus multilocularis | WD repeat containing protein 48 | 0.0117 | 0.5088 | 0.5056 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1281 | 0.1281 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0042 | 0.0065 | 0.0065 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1281 | 0.1281 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0042 | 0.0065 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0042 | 0.0065 | 0.5 |
Echinococcus granulosus | WD repeat containing protein 48 | 0.0117 | 0.5088 | 0.5056 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1281 | 0.1281 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0042 | 0.0065 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0042 | 0.0065 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.1711 | 0.2081 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0042 | 0.0065 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0042 | 0.0065 | 0.5 |
Schistosoma mansoni | alpha glucosidase | 0.0042 | 0.0065 | 0.0079 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.5088 | 0.5088 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.0065 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0609 | 0.0741 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.9953 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.