Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | lipase LipD | 0.0041 | 0.0037 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.0037 | 0.0023 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0037 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0041 | 0.0037 | 0.0023 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0041 | 0.0037 | 0.0008 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0037 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0037 | 0.0023 |
Mycobacterium ulcerans | hypothetical protein | 0.0041 | 0.0037 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.0037 | 0.0221 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0261 | 0.166 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0041 | 0.0037 | 0.0023 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0037 | 0.0023 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.0265 | 0.0448 |
Loa Loa (eye worm) | RNA binding protein | 0.0072 | 0.0265 | 0.1659 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0041 | 0.0037 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.0931 | 0.6371 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0037 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.038 | 0.2539 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0072 | 0.0265 | 0.1659 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0037 | 0.004 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0037 | 0.0008 |
Brugia malayi | RNA binding protein | 0.0072 | 0.0265 | 0.0327 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.038 | 0.2539 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.0265 | 0.0448 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0041 | 0.0037 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0232 | 0.1443 | 0.1971 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0041 | 0.0037 | 0.0221 |
Brugia malayi | TAR-binding protein | 0.0072 | 0.0265 | 0.0327 |
Mycobacterium leprae | conserved hypothetical protein | 0.0041 | 0.0037 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0037 | 0.004 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0041 | 0.0037 | 0.0221 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0037 | 0.0011 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0037 | 0.004 |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.0037 | 0.0221 |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.0037 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.0931 | 0.6371 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0037 | 0.004 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.0265 | 0.0448 |
Leishmania major | telomerase reverse transcriptase, putative | 0.038 | 0.2539 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0037 | 0.0011 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.0265 | 0.0448 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0232 | 0.1443 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.038 | 0.2539 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0749 | 0.5258 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.038 | 0.2539 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0749 | 0.5258 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0162 | 0.0931 | 0.1722 |
Giardia lamblia | Telomerase catalytic subunit | 0.038 | 0.2539 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0037 | 0.004 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0041 | 0.0037 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.0265 | 0.0448 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0041 | 0.0037 | 0.0221 |
Brugia malayi | Muscleblind-like protein | 0.0162 | 0.0931 | 0.1256 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0072 | 0.0265 | 0.0327 |
Brugia malayi | beta-lactamase | 0.0041 | 0.0037 | 0.0008 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0232 | 0.1443 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0749 | 0.5258 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.038 | 0.2539 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0072 | 0.0265 | 0.0448 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0037 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.1012 | 0.7196 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0041 | 0.0037 | 0.0011 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0041 | 0.0037 | 0.0011 |
Loa Loa (eye worm) | TAR-binding protein | 0.0072 | 0.0265 | 0.1659 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.004 | 0.0031 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0037 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0041 | 0.0037 | 0.004 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.038 | 0.2539 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0041 | 0.0037 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0072 | 0.0265 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0037 | 0.004 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0037 | 0.0008 |
Echinococcus granulosus | muscleblind protein | 0.0162 | 0.0931 | 0.1722 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0041 | 0.0037 | 0.0221 |
Mycobacterium leprae | Probable lipase LipE | 0.0041 | 0.0037 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0041 | 0.0037 | 0.004 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0041 | 0.0037 | 0.0221 |
Echinococcus multilocularis | muscleblind protein | 0.0162 | 0.0931 | 0.1722 |
Trichomonas vaginalis | esterase, putative | 0.0041 | 0.0037 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0041 | 0.0037 | 0.0221 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.004 | 0.0031 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.