Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | lanosterol synthase, putative | 0.0321 | 0.8031 | 0.5 |
Onchocerca volvulus | Putative nachr subunit | 0.0187 | 0 | 0.5 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0187 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.107 | 0.5 |
Mycobacterium tuberculosis | Halimadienyl diphosphate synthase | 0.0247 | 0.3576 | 0.5 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0187 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.107 | 0.5 |
Echinococcus granulosus | geminin | 0.0205 | 0.107 | 1 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0354 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 0.107 | 1 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0354 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.3109 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.