Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.1128 | 0.2545 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0203 | 0.0458 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0203 | 0.0458 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0457 | 0.4433 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0147 | 0.1128 | 0.2545 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.1128 | 0.2545 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0147 | 0.1128 | 0.2545 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0147 | 0.1128 | 0.2545 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0203 | 0.0458 |
Loa Loa (eye worm) | serotonin transporter b | 0.0147 | 0.1128 | 0.2545 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0203 | 0.0458 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0358 | 0.338 | 0.7624 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0358 | 0.338 | 0.5 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0457 | 0.4433 | 1 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0457 | 0.4433 | 0.3725 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0457 | 0.4433 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0358 | 0.338 | 0.7624 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0457 | 0.4433 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0147 | 0.1128 | 0.2545 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0147 | 0.1128 | 0.2545 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0358 | 0.338 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0147 | 0.1128 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.1513 | 0.3413 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0358 | 0.338 | 0.5 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0457 | 0.4433 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.1128 | 0.2545 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.