Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0519 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0519 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0519 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0519 | 1 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0519 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0519 | 1 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0519 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0519 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0519 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0519 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0519 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0519 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0519 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.035 | 0.3182 | 0.3182 |
Loa Loa (eye worm) | hypothetical protein | 0.0389 | 0.4737 | 0.2281 |
Echinococcus multilocularis | cathepsin b | 0.0389 | 0.4737 | 0.4737 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0519 | 1 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0519 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0519 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0519 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0519 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0519 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0389 | 0.4737 | 0.4737 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0519 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0519 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0519 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0519 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0519 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0519 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0519 | 1 | 0.5 |
Entamoeba histolytica | cysteine protease, putative | 0.0519 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0519 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0519 | 1 | 0.5 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.035 | 0.3182 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0519 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.035 | 0.3182 | 0.3182 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0519 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0519 | 1 | 1 |
Onchocerca volvulus | 0.0519 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0519 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.035 | 0.3182 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0519 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0519 | 1 | 0.5 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0519 | 1 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0519 | 1 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0389 | 0.4737 | 0.4737 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0519 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0519 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0519 | 1 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.035 | 0.3182 | 0.3182 |
Plasmodium vivax | vivapain-2 | 0.0519 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0519 | 1 | 1 |
Onchocerca volvulus | 0.0519 | 1 | 1 | |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0389 | 0.4737 | 0.4737 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0519 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0519 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0519 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0519 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0519 | 1 | 1 |
Onchocerca volvulus | 0.0519 | 1 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0519 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0519 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0519 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0519 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.035 | 0.3182 | 0.3182 |
Echinococcus granulosus | cathepsin l1 | 0.0519 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0519 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0519 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0519 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0389 | 0.4737 | 0.4737 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0389 | 0.4737 | 0.4737 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0519 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0519 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.035 | 0.3182 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0519 | 1 | 1 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0389 | 0.4737 | 0.4737 |
Echinococcus granulosus | cathepsin b | 0.0389 | 0.4737 | 0.4737 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0519 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0519 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0519 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0519 | 1 | 1 |
Onchocerca volvulus | 0.0519 | 1 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0519 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0519 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.035 | 0.3182 | 0.3182 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0519 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0519 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0519 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0519 | 1 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.0389 | 0.4737 | 0.4737 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0519 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0519 | 1 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0519 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0519 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0389 | 0.4737 | 0.4737 |
Leishmania major | cathepsin L-like protease | 0.0519 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.035 | 0.3182 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0519 | 1 | 1 |
Onchocerca volvulus | 0.0519 | 1 | 1 | |
Brugia malayi | cathepsin L-like precursor | 0.035 | 0.3182 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0519 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0519 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0519 | 1 | 1 |
Onchocerca volvulus | 0.0519 | 1 | 1 | |
Onchocerca volvulus | Cathepsin L homolog | 0.0519 | 1 | 1 |
Onchocerca volvulus | 0.0519 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0519 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0519 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC25 (functional) | > 10000 nM | Effective concentration required to increase time to the onset of contracture (TTC) in globally ischemic rat hearts | ChEMBL. | 9464357 |
IC50 (functional) | = 12800 nM | Inhibitory concentration against methoxamine-induced contractions in rat aorta | ChEMBL. | 9464357 |
Ki (binding) | > 30000 nM | Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes | ChEMBL. | 9464357 |
Ki (binding) | > 30000 nM | Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes | ChEMBL. | 9464357 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.