Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | acetylornithine transaminase protein | 0.0045 | 0.1149 | 0.5 |
Mycobacterium tuberculosis | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA | 0.0319 | 1 | 1 |
Schistosoma mansoni | ornithine--oxo-acid transaminase | 0.0045 | 0.1149 | 1 |
Echinococcus multilocularis | Aminotransferase class III | 0.0045 | 0.1149 | 1 |
Brugia malayi | 4-aminobutyrate aminotransferase, mitochondrial precursor | 0.0045 | 0.1149 | 0.2644 |
Echinococcus granulosus | Aminotransferase class III | 0.0045 | 0.1149 | 1 |
Echinococcus multilocularis | ornithine aminotransferase | 0.0045 | 0.1149 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.4346 | 1 |
Toxoplasma gondii | ornithine aminotransferase, mitochondrial precursor, putative | 0.0045 | 0.1149 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0319 | 1 | 1 |
Trichomonas vaginalis | acetylornithine aminotransferase, putative | 0.0319 | 1 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.4346 | 1 |
Plasmodium falciparum | ornithine aminotransferase | 0.0045 | 0.1149 | 0.5 |
Echinococcus multilocularis | ornithine aminotransferase | 0.0045 | 0.1149 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.4346 | 1 |
Echinococcus granulosus | ornithine aminotransferase | 0.0045 | 0.1149 | 1 |
Mycobacterium tuberculosis | Probable aminotransferase | 0.0319 | 1 | 1 |
Mycobacterium ulcerans | adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 0.0319 | 1 | 1 |
Chlamydia trachomatis | glutamate-1-semialdehyde-2,1-aminomutase | 0.0045 | 0.1149 | 0.5 |
Plasmodium vivax | ornithine aminotransferase, putative | 0.0045 | 0.1149 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.