Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0051 | 0.0829 | 0.5 |
Echinococcus granulosus | caspase 3 | 0.0072 | 0.1755 | 0.1362 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.6459 | 0.6139 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0167 | 0.6053 | 0.5697 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0098 | 0.2934 | 0.7301 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0167 | 0.6053 | 0.5 |
Echinococcus multilocularis | caspase 3 | 0.0072 | 0.1755 | 0.1362 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0098 | 0.2934 | 0.7301 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0255 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0167 | 0.6053 | 0.5697 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.7626 | 0.7626 |
Echinococcus granulosus | caspase | 0.0098 | 0.2934 | 0.3098 |
Schistosoma mansoni | hypothetical protein | 0.0087 | 0.2436 | 0.5572 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0167 | 0.6053 | 0.5697 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0051 | 0.0829 | 0.5 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0051 | 0.0829 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0829 | 0.0829 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0098 | 0.2934 | 0.3098 |
Echinococcus multilocularis | caspase | 0.0098 | 0.2934 | 0.3098 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0167 | 0.6053 | 0.5697 |
Toxoplasma gondii | hypothetical protein | 0.0115 | 0.3713 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0087 | 0.2436 | 0.5572 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0255 | 1 | 1 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0051 | 0.0829 | 0.5 |
Brugia malayi | Hypothetical WD-repeat protein F35G12.4 in chromosome III | 0.0202 | 0.7626 | 0.7626 |
Schistosoma mansoni | hypothetical protein | 0.0115 | 0.3713 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0167 | 0.6053 | 0.5697 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0051 | 0.0829 | 0.0829 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0051 | 0.0829 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0255 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0167 | 0.6053 | 0.5697 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0098 | 0.2934 | 0.3098 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0051 | 0.0829 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.6459 | 0.6139 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0167 | 0.6053 | 0.5697 |
Echinococcus granulosus | WD repeat containing protein 48 | 0.0202 | 0.7626 | 1 |
Echinococcus multilocularis | WD repeat containing protein 48 | 0.0202 | 0.7626 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0255 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0255 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0255 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.14 uM | PUBCHEM_BIOASSAY: qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation in HepG2 cytotox. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540272] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Giardia lamblia |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.