Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | caspase-7 (C14 family) | 0.0102 | 0.7623 | 1 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0102 | 0.7623 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0129 | 1 | 1 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0102 | 0.7623 | 1 |
Echinococcus multilocularis | caspase 2 | 0.0027 | 0.0923 | 0.1211 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0027 | 0.0923 | 0.1211 |
Entamoeba histolytica | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0069 | 0.4595 | 0.5 |
Echinococcus granulosus | caspase 3 | 0.0075 | 0.5177 | 0.6792 |
Echinococcus multilocularis | sentrin specific protease 8 | 0.0069 | 0.4595 | 0.6029 |
Echinococcus granulosus | sentrin specific protease 8 | 0.0069 | 0.4595 | 0.6029 |
Brugia malayi | Cell death protein 3 precursor | 0.0027 | 0.0923 | 0.0923 |
Trypanosoma brucei | metacaspase 5, putative | 0.0027 | 0.0923 | 0.5 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0069 | 0.4595 | 1 |
Echinococcus granulosus | caspase 8 | 0.0027 | 0.0923 | 0.1211 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.3289 | 0.3289 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0069 | 0.4595 | 0.6029 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0027 | 0.0923 | 0.0923 |
Trypanosoma brucei | metacaspase MCA3 | 0.0027 | 0.0923 | 0.5 |
Echinococcus granulosus | caspase | 0.0102 | 0.7623 | 1 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0027 | 0.0923 | 0.5 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0027 | 0.0923 | 0.5 |
Brugia malayi | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0069 | 0.4595 | 0.4595 |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.0027 | 0.0923 | 0.1211 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.1767 | 0.1767 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.3289 | 0.3289 |
Plasmodium falciparum | metacaspase-like protein | 0.0027 | 0.0923 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.3289 | 0.3289 |
Leishmania major | metacaspase, putative | 0.0027 | 0.0923 | 0.5 |
Echinococcus multilocularis | caspase | 0.0102 | 0.7623 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0129 | 1 | 1 |
Trypanosoma brucei | Metacaspase-4 | 0.0027 | 0.0923 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0923 | 0.0923 |
Echinococcus granulosus | caspase 2 | 0.0027 | 0.0923 | 0.1211 |
Trypanosoma brucei | metacaspase MCA2 | 0.0027 | 0.0923 | 0.5 |
Plasmodium vivax | metacaspase 1, putative | 0.0027 | 0.0923 | 0.5 |
Trypanosoma cruzi | hypothetical protein | 0.0069 | 0.4595 | 1 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0069 | 0.4595 | 1 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0027 | 0.0923 | 0.5 |
Echinococcus multilocularis | caspase 3 | 0.0075 | 0.5177 | 0.6792 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1767 | 0.1767 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0027 | 0.0923 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1767 | 0.2318 |
Trichomonas vaginalis | Sentrin-specific protease, putative | 0.0069 | 0.4595 | 1 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0102 | 0.7623 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.3289 | 0.3289 |
Plasmodium vivax | hypothetical protein, conserved | 0.0027 | 0.0923 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0923 | 0.0923 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0069 | 0.4595 | 1 |
Plasmodium falciparum | metacaspase 1 | 0.0027 | 0.0923 | 0.5 |
Echinococcus multilocularis | caspase 8 | 0.0027 | 0.0923 | 0.1211 |
Loa Loa (eye worm) | Ulp1 protease | 0.0069 | 0.4595 | 0.4595 |
Trypanosoma brucei | metacaspase | 0.0027 | 0.0923 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.6511 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 42.2841 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.