Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0218 | 0.129 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0375 | 0.329 | 0.329 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0218 | 0.129 | 0.1624 |
Echinococcus multilocularis | carbonic anhydrase | 0.0375 | 0.329 | 0.329 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0375 | 0.329 | 0.329 |
Schistosoma mansoni | carbonic anhydrase | 0.0375 | 0.329 | 0.329 |
Loa Loa (eye worm) | hypothetical protein | 0.0375 | 0.329 | 0.329 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0904 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0375 | 0.329 | 0.329 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0904 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0375 | 0.329 | 0.329 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0375 | 0.329 | 0.329 |
Echinococcus multilocularis | carbonic anhydrase | 0.0375 | 0.329 | 0.329 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0375 | 0.329 | 0.329 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0904 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0375 | 0.329 | 0.329 |
Plasmodium vivax | hypothetical protein, conserved | 0.0116 | 0 | 0.5 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0904 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0375 | 0.329 | 0.329 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0375 | 0.329 | 0.329 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0218 | 0.129 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0504 | 0.4918 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0504 | 0.4918 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0904 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0504 | 0.4918 | 0.4918 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0904 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0904 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0904 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0904 | 1 | 1 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0375 | 0.329 | 0.329 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0742 | 0.7944 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0375 | 0.329 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0375 | 0.329 | 0.329 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0504 | 0.4918 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0904 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0375 | 0.329 | 0.329 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0504 | 0.4918 | 0.4918 |
Plasmodium falciparum | carbonic anhydrase | 0.0375 | 0.329 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0375 | 0.329 | 0.329 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0218 | 0.129 | 0.2623 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0375 | 0.329 | 0.329 |
Echinococcus granulosus | carbonic anhydrase II | 0.0904 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0375 | 0.329 | 0.329 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0286 | 0.2154 | 0.2712 |
Loa Loa (eye worm) | hypothetical protein | 0.0375 | 0.329 | 0.329 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 1000 nM | Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells | ChEMBL. | 11591514 |
IC50 (binding) | > 1000 nM | Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells | ChEMBL. | 11591514 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.