Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | 0.237 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0091 | 0.0046 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.237 | 1 | 1 |
Schistosoma mansoni | alkaline phosphatase | 0.0196 | 0.0752 | 0.0667 |
Schistosoma mansoni | hypothetical protein | 0.0102 | 0.0351 | 0.0261 |
Brugia malayi | hypothetical protein | 0.003 | 0.0046 | 0.0046 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0173 | 0.0173 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.053 | 0.0486 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0881 | 0.3666 | 0.3637 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0046 | 0.5 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.237 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0173 | 0.0127 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.053 | 0.053 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.0881 | 0.3666 | 0.3637 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.237 | 1 | 1 |
Schistosoma mansoni | alkaline phosphatase | 0.0196 | 0.0752 | 0.0667 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0881 | 0.3666 | 0.3637 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.053 | 0.0486 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0881 | 0.3666 | 0.3637 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.237 | 1 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.237 | 1 | 1 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0881 | 0.3666 | 0.3637 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0173 | 0.0173 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.237 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0091 | 0.0091 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.237 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0046 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0173 | 0.0127 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.237 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0046 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 84.9214 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.