Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0795 | 0.1033 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0044 | 0.1006 | 0.0829 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0193 | 0.5 |
Onchocerca volvulus | 0.0062 | 0.159 | 0.1159 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1223 | 0.1192 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0795 | 0.0743 |
Brugia malayi | Pre-SET motif family protein | 0.0234 | 0.7351 | 0.7587 |
Loa Loa (eye worm) | glutaminase 2 | 0.0302 | 0.9627 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0608 | 0.322 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0795 | 0.0743 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0193 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1223 | 0.7015 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0062 | 0.159 | 0.148 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0194 | 0.6016 | 0.6249 |
Plasmodium vivax | SET domain protein, putative | 0.0035 | 0.0694 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0062 | 0.159 | 0.1576 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0194 | 0.6016 | 0.6249 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0165 | 0.5047 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1223 | 0.1192 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0313 | 1 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0065 | 0.1707 | 0.1699 |
Onchocerca volvulus | 0.0266 | 0.8425 | 1 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.006 | 0.1532 | 0.1365 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0194 | 0.6016 | 0.6249 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0795 | 0.0638 |
Onchocerca volvulus | 0.0194 | 0.6016 | 0.6885 | |
Leishmania major | hypothetical protein, conserved | 0.006 | 0.1532 | 0.1365 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0795 | 0.1033 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0193 | 0.0201 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.1223 | 0.1092 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0035 | 0.0694 | 0.375 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0035 | 0.0694 | 0.375 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.006 | 0.1532 | 0.1592 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0148 | 0.4487 | 0.4379 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.0694 | 0.0637 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0118 | 0.347 | 1 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0044 | 0.1006 | 0.0829 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0694 | 0.0531 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.002 | 0.0203 | 0.001 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0234 | 0.7351 | 0.7587 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0193 | 0.5 |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.0194 | 0.6016 | 0.6172 |
Loa Loa (eye worm) | histone methyltransferase | 0.002 | 0.0211 | 0.0019 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0194 | 0.6016 | 1 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.0134 | 0.4018 | 0.788 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0795 | 0.4375 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0035 | 0.0694 | 0.1528 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0194 | 0.6016 | 0.6172 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0148 | 0.4487 | 0.4379 |
Loa Loa (eye worm) | glutaminase | 0.0302 | 0.9627 | 1 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0194 | 0.6016 | 0.6249 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1223 | 0.7015 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0795 | 0.1033 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0313 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1223 | 0.7015 |
Trichomonas vaginalis | glutaminase, putative | 0.0302 | 0.9627 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0044 | 0.1006 | 0.0829 |
Schistosoma mansoni | glutaminase | 0.0302 | 0.9627 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0193 | 0.0201 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0194 | 0.6016 | 0.6249 |
Echinococcus multilocularis | cpg binding protein | 0.0065 | 0.1707 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0313 | 1 | 1 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.006 | 0.1532 | 0.1592 |
Brugia malayi | Pre-SET motif family protein | 0.0035 | 0.0694 | 0.0531 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1223 | 0.1192 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0795 | 0.4375 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.002 | 0.0211 | 0.0773 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0148 | 0.4487 | 0.4379 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0044 | 0.1006 | 0.0829 |
Echinococcus granulosus | cpg binding protein | 0.0065 | 0.1707 | 1 |
Mycobacterium ulcerans | glutaminase | 0.0302 | 0.9627 | 1 |
Trypanosoma brucei | low molecular weight protein tyrosine phosphatase, putative | 0.006 | 0.1532 | 0.1365 |
Schistosoma mansoni | cpg binding protein | 0.0065 | 0.1707 | 0.1699 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0193 | 0.0663 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0193 | 0.0113 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.0694 | 0.0637 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0194 | 0.6016 | 0.6249 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.002 | 0.0211 | 0.0773 |
Mycobacterium ulcerans | hypothetical protein | 0.0165 | 0.5047 | 0.5145 |
Trichomonas vaginalis | set domain proteins, putative | 0.0266 | 0.8425 | 0.8751 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0035 | 0.0694 | 0.0637 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0054 | 0.1328 | 0.1157 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0194 | 0.6016 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0035 | 0.0694 | 0.375 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0193 | 0.0663 |
Brugia malayi | CXXC zinc finger family protein | 0.0062 | 0.159 | 0.148 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.006 | 0.1532 | 0.1365 |
Toxoplasma gondii | hypothetical protein | 0.0051 | 0.1222 | 0.3141 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0795 | 0.1033 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.0694 | 0.0637 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0132 | 0.3935 | 0.4035 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0193 | 0.0113 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1223 | 0.7015 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.1223 | 0.1092 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0194 | 0.6016 | 0.6172 |
Brugia malayi | glutaminase DH11.1 | 0.0302 | 0.9627 | 1 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0194 | 0.6016 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 56.2341 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.