Detailed information for compound 1549205

Basic information

Technical information
  • TDR Targets ID: 1549205
  • Name: 2-[(5-furan-2-yl-1H-1,2,4-triazol-3-yl)sulfan yl]-N-(2-methoxyphenyl)acetamide
  • MW: 330.362 | Formula: C15H14N4O3S
  • H donors: 2 H acceptors: 3 LogP: 2.47 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1NC(=O)CSc1n[nH]c(n1)c1ccco1
  • InChi: 1S/C15H14N4O3S/c1-21-11-6-3-2-5-10(11)16-13(20)9-23-15-17-14(18-19-15)12-7-4-8-22-12/h2-8H,9H2,1H3,(H,16,20)(H,17,18,19)
  • InChiKey: CUHJEAZJHCBGBZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[5-(2-furyl)-1H-1,2,4-triazol-3-yl]sulfanyl]-N-(2-methoxyphenyl)acetamide
  • 2-[[5-(2-furyl)-1H-1,2,4-triazol-3-yl]thio]-N-(2-methoxyphenyl)acetamide
  • 2-[(5-furan-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]-N-(2-methoxyphenyl)ethanamide
  • ZINC00798765
  • 2-(5-Furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanyl)-N-(2-methoxy-phenyl)-acetamide
  • BAS 06195308

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0279 0.32 1
Trichomonas vaginalis conserved hypothetical protein 0.0279 0.32 0.5
Echinococcus granulosus SWI:SNF matrix associated 0.0279 0.32 0.2742
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0099 0.0632 1
Brugia malayi YY1-associated factor 2 0.0099 0.0632 0.1974
Loa Loa (eye worm) hypothetical protein 0.011 0.0792 0.2476
Loa Loa (eye worm) hypothetical protein 0.0099 0.0632 0.1974
Trypanosoma cruzi hypothetical protein, conserved 0.0099 0.0632 1
Brugia malayi brahma associated protein 60 kDa 0.0279 0.32 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0632 0.1974
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0099 0.0632 1
Leishmania major hypothetical protein, conserved 0.0099 0.0632 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0055 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0099 0.0632 0.1974
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0099 0.0632 0.1974
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0099 0.0632 1
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0099 0.0632 0.1974
Schistosoma mansoni hypothetical protein 0.0279 0.32 1
Trypanosoma brucei hypothetical protein, conserved 0.0099 0.0632 1
Schistosoma mansoni cellular tumor antigen P53 0.011 0.0792 0.0625
Schistosoma mansoni brg-1 associated factor 0.0279 0.32 1
Trypanosoma cruzi hypothetical protein, conserved 0.0099 0.0632 1
Leishmania major hypothetical protein, conserved 0.0099 0.0632 1
Chlamydia trachomatis DNA topoisomerase I 0.0279 0.32 0.5
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0279 0.32 0.5
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0099 0.0632 0.1974
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0099 0.0632 0.1974
Trypanosoma cruzi hypothetical protein, conserved 0.0099 0.0632 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0632 0.1974
Brugia malayi SWIB/MDM2 domain containing protein 0.0279 0.32 1
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0279 0.32 1
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0279 0.32 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0279 0.32 0.2742
Echinococcus multilocularis SWI:SNF matrix associated 0.0279 0.32 0.2742
Leishmania major hypothetical protein, conserved 0.0099 0.0632 1
Echinococcus multilocularis tumor protein p63 0.0754 1 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0279 0.32 0.2742
Schistosoma mansoni hypothetical protein 0.0279 0.32 1
Onchocerca volvulus 0.0279 0.32 1
Brugia malayi brahma associated protein 60 kDa 0.0279 0.32 1
Leishmania major hypothetical protein, conserved 0.0099 0.0632 1
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0279 0.32 0.2742
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0279 0.32 1
Leishmania major hypothetical protein, conserved 0.0099 0.0632 1
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0099 0.0632 1
Onchocerca volvulus 0.011 0.0792 0.0625
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0279 0.32 1
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0099 0.0632 1
Trypanosoma cruzi WLM domain containing protein, putative 0.0099 0.0632 1
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0099 0.0632 1
Trypanosoma cruzi WLM domain containing protein, putative 0.0099 0.0632 1
Plasmodium vivax hypothetical protein, conserved 0.0279 0.32 0.5
Loa Loa (eye worm) brahma associated protein 0.0279 0.32 1
Trypanosoma brucei hypothetical protein, conserved 0.0099 0.0632 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0632 0.1974
Chlamydia trachomatis SWIB complex protein 0.0279 0.32 0.5
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0279 0.32 0.2742
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0099 0.0632 1
Schistosoma mansoni hypothetical protein 0.0279 0.32 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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