Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | macrophage expressed protein | 0.0225 | 0.8219 | 0.8079 |
Echinococcus granulosus | NADH dehydrogenase ubiquinone flavoprotein 1 | 0.0051 | 0.098 | 0.0272 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0268 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0045 | 0.0728 | 0.1911 |
Brugia malayi | NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor | 0.0051 | 0.098 | 0.5093 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1369 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0728 | 0.016 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0728 | 0.1911 |
Schistosoma mansoni | rab6-interacting | 0.0045 | 0.0728 | 0.016 |
Trypanosoma cruzi | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0051 | 0.098 | 0.5 |
Schistosoma mansoni | loxhd1 | 0.0045 | 0.0728 | 0.016 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0728 | 0.1911 |
Trypanosoma brucei | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | 0.0051 | 0.098 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0268 | 1 | 1 |
Loa Loa (eye worm) | doublecortin family protein | 0.0045 | 0.0728 | 0.1911 |
Trypanosoma brucei | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative | 0.0051 | 0.098 | 0.5 |
Loa Loa (eye worm) | NADH-ubiquinone oxidoreductase 51 kDa subunit | 0.0051 | 0.098 | 0.5093 |
Trichomonas vaginalis | NADH-ubiquinone oxidoreductase flavoprotein, putative | 0.0051 | 0.098 | 0.5 |
Schistosoma mansoni | rab6-interacting | 0.0045 | 0.0728 | 0.016 |
Leishmania major | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0051 | 0.098 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1369 | 1 |
Brugia malayi | hypothetical protein | 0.0045 | 0.0728 | 0.1911 |
Mycobacterium ulcerans | NADH dehydrogenase I subunit F | 0.0051 | 0.098 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0187 | 0.665 | 0.6445 |
Schistosoma mansoni | polycystin 1-related | 0.0045 | 0.0728 | 0.016 |
Echinococcus multilocularis | macrophage expressed protein | 0.0225 | 0.8219 | 0.8079 |
Echinococcus multilocularis | NADH dehydrogenase (ubiquinone) flavoprotein 1 | 0.0051 | 0.098 | 0.0272 |
Trypanosoma cruzi | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0051 | 0.098 | 0.5 |
Trichomonas vaginalis | NADH-ubiquinone oxidoreductase flavoprotein, putative | 0.0051 | 0.098 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1369 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0045 | 0.0728 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1369 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) | 0.0051 | 0.098 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0225 | 0.8219 | 0.811 |
Wolbachia endosymbiont of Brugia malayi | NADH dehydrogenase I subunit F | 0.0051 | 0.098 | 0.5 |
Onchocerca volvulus | 0.0045 | 0.0728 | 1 | |
Brugia malayi | Doublecortin family protein | 0.0045 | 0.0728 | 0.1911 |
Onchocerca volvulus | 0.0045 | 0.0728 | 1 | |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0045 | 0.0728 | 0.5 |
Schistosoma mansoni | NADH-ubiquinone oxidoreductase | 0.0051 | 0.098 | 0.0428 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.