Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0418 | 0.1243 | 1 |
Brugia malayi | hypothetical protein | 0.0418 | 0.1243 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0418 | 0.1243 | 1 |
Echinococcus granulosus | macrophage expressed protein | 0.1737 | 0.723 | 0.6836 |
Schistosoma mansoni | lipoxygenase | 0.2348 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.1595 | 0.6584 | 0.6099 |
Loa Loa (eye worm) | doublecortin family protein | 0.0418 | 0.1243 | 1 |
Toxoplasma gondii | perforin-like protein PLP1 | 0.0192 | 0.0217 | 0.5 |
Brugia malayi | Doublecortin family protein | 0.0418 | 0.1243 | 1 |
Echinococcus multilocularis | macrophage expressed protein | 0.1737 | 0.723 | 0.6836 |
Toxoplasma gondii | MAC/Perforin domain-containing protein | 0.0192 | 0.0217 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.2348 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0418 | 0.1243 | 1 |
Onchocerca volvulus | 0.0418 | 0.1243 | 0.5 | |
Plasmodium falciparum | LCCL domain-containing protein | 0.0418 | 0.1243 | 1 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0418 | 0.1243 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1737 | 0.723 | 0.6836 |
Onchocerca volvulus | 0.0418 | 0.1243 | 0.5 | |
Chlamydia trachomatis | hypothetical protein | 0.0192 | 0.0217 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.