Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | sirtuin 5 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | SIR2-like protein 4, putative | sirtuin 5 | 292 aa | 272 aa | 29.0 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0665 | 1 | 1 |
Trypanosoma cruzi | Silent information regulator 2 related protein 3 | 0.0062 | 0.0319 | 0.5 |
Schistosoma mansoni | loxhd1 | 0.0111 | 0.1105 | 0.0812 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0062 | 0.0319 | 0.5 |
Plasmodium falciparum | transcriptional regulatory protein sir2a | 0.0062 | 0.0319 | 0.0097 |
Leishmania major | NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe | 0.0062 | 0.0319 | 0.5 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0111 | 0.1105 | 1 |
Mycobacterium tuberculosis | Transcriptional regulatory protein | 0.0062 | 0.0319 | 0.5 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0062 | 0.0319 | 0.5 |
Mycobacterium leprae | Probable NAD-dependent deacetylase NpdA (Regulatory protein SIR2 homolog) | 0.0042 | 0 | 0.5 |
Giardia lamblia | Transcriptional regulator, Sir2 family | 0.0062 | 0.0319 | 0.5 |
Brugia malayi | Doublecortin family protein | 0.0111 | 0.1105 | 0.6066 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.1635 | 1 |
Trypanosoma cruzi | Silent information regulator 2 related protein 3 | 0.0062 | 0.0319 | 0.5 |
Onchocerca volvulus | 0.0111 | 0.1105 | 0.5 | |
Trypanosoma brucei | Silent information regulator 2 related protein 3 | 0.0062 | 0.0319 | 0.5 |
Echinococcus granulosus | macrophage expressed protein | 0.0558 | 0.8291 | 0.8079 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.1635 | 1 |
Brugia malayi | hypothetical protein | 0.0111 | 0.1105 | 0.6066 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0062 | 0.0319 | 0.5 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0062 | 0.0319 | 0.5 |
Echinococcus multilocularis | macrophage expressed protein | 0.0558 | 0.8291 | 0.8079 |
Schistosoma mansoni | rab6-interacting | 0.0111 | 0.1105 | 0.0812 |
Toxoplasma gondii | histone deacetylase SIR2 | 0.0062 | 0.0319 | 1 |
Mycobacterium ulcerans | NAD-dependent deacetylase | 0.0062 | 0.0319 | 0.5 |
Brugia malayi | hypothetical protein | 0.0111 | 0.1105 | 0.6066 |
Schistosoma mansoni | lipoxygenase | 0.0465 | 0.6786 | 0.668 |
Schistosoma mansoni | lipoxygenase | 0.0665 | 1 | 1 |
Schistosoma mansoni | polycystin 1-related | 0.0111 | 0.1105 | 0.0812 |
Chlamydia trachomatis | hypothetical protein | 0.0062 | 0.0311 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0111 | 0.1105 | 0.0812 |
Schistosoma mansoni | hypothetical protein | 0.0558 | 0.8291 | 0.8235 |
Plasmodium vivax | NAD-dependent deacetylase, putative | 0.0062 | 0.0319 | 0.0097 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.1635 | 1 |
Loa Loa (eye worm) | doublecortin family protein | 0.0111 | 0.1105 | 0.6066 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0111 | 0.1105 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1105 | 0.6066 |
Onchocerca volvulus | 0.0111 | 0.1105 | 0.5 | |
Schistosoma mansoni | rab6-interacting | 0.0111 | 0.1105 | 0.0812 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1105 | 0.6066 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (binding) | 17.02 uM | PubChem BioAssay. MLPCN SirT-5 Measured in Biochemical System Using Imaging - 7044-01_Inhibitor_Dose_CherryPick_Activity_Set5. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.