TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 264.3 | Formula: C12H12N2O3S
H donors: 1 H acceptors: 2 LogP: 2.28 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)S(=O)(=O)NN=Cc1ccco1
InChi: 1S/C12H12N2O3S/c1-10-4-6-12(7-5-10)18(15,16)14-13-9-11-3-2-8-17-11/h2-9,14H,1H3
InChiKey: QHAQHUCZLYGDLT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0958	0.2509
Loa Loa (eye worm)	TK/INSR protein kinase	0.0122	0.2651	0.6945
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0049	0.0789	0.2068
Schistosoma mansoni	lipoxygenase	0.0049	0.0789	0.0789
Echinococcus granulosus	tyrosine kinase	0.0065	0.1212	0.3175
Schistosoma mansoni	hypothetical protein	0.0019	0.0043	0.0043
Loa Loa (eye worm)	prolyl oligopeptidase	0.0018	0.0008	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0008	0.0021
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0072	0.1387	0.3635
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0933	0.2445
Echinococcus granulosus	tyrosine protein kinase Blk	0.0065	0.1212	0.3175
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0075	0.1446	0.3774
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0075	0.1446	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0043	0.0113
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.01	0.2091	0.5478
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0043	0.0113
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0018	0.0008	0.0008
Loa Loa (eye worm)	TK protein kinase	0.0065	0.1212	0.3175
Mycobacterium tuberculosis	Probable protease II PtrBb [second part] (oligopeptidase B)	0.0067	0.1254	0.1351
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0072	0.1387	0.3635
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0057	0.0994	0.2605
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.01	0.2091	0.2091
Echinococcus granulosus	prolyl endopeptidase	0.0168	0.3817	1
Trypanosoma cruzi	prolyl endopeptidase	0.0168	0.3817	1
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0054	0.0923	0.2403
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0067	0.1254	0.3271
Trypanosoma cruzi	oligopeptidase b	0.0067	0.1254	0.3271
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0008	0.0021
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0958	0.0958
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0018	0.0008	0.0021
Echinococcus granulosus	insulin receptor	0.0122	0.2651	0.6945
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0057	0.0994	0.2605
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0122	0.2651	0.6945
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0047	0.0751	0.1969
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0043	0.0113
Echinococcus granulosus	proteasome prosome macropain	0.0075	0.1446	0.3787
Echinococcus multilocularis	acetylcholinesterase	0.0054	0.0933	0.2445
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0049	0.0789	0.2068
Leishmania major	proteasome beta 5 subunit, putative	0.0075	0.1446	0.3774
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0062	0.1137	0.2978
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.01	0.2091	0.5478
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0958	0.2509
Plasmodium vivax	hypothetical protein, conserved	0.0018	0.0008	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0933	0.2445
Echinococcus multilocularis	prolyl endopeptidase	0.0168	0.3817	1
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0054	0.0923	0.2419
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0168	0.3817	0.3817
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0065	0.1212	0.3175
Plasmodium falciparum	peptidase, putative	0.0018	0.0008	0.0054
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0043	0.0113
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0043	0.0113
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0958	0.2509
Schistosoma mansoni	tyrosine kinase	0.0122	0.2651	0.2651
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0072	0.1387	0.3635
Echinococcus granulosus	acylamino acid releasing enzyme	0.0018	0.0008	0.0021
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0054	0.0933	0.0933
Echinococcus granulosus	acetylcholinesterase	0.0054	0.0933	0.2445
Schistosoma mansoni	acylaminoacyl-peptidase (S09 family)	0.0018	0.0008	0.0008
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0075	0.1446	0.3774
Echinococcus granulosus	epidermal growth factor receptor	0.0057	0.0994	0.2605
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0072	0.1387	0.3635
Brugia malayi	Furin-like cysteine rich region family protein	0.0057	0.0994	0.2605
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0088	0.1783	0.4671
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0072	0.1387	0.3635
Schistosoma mansoni	tyrosine kinase	0.0072	0.1387	0.1387
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0072	0.1387	0.3635
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0122	0.2651	0.6945
Brugia malayi	protein-tyrosine kinase	0.0065	0.1212	0.3175
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0075	0.1446	0.6902
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0958	0.2509
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0054	0.0923	0.0923
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0058	0.1032	0.2703
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0088	0.1783	0.4671
Leishmania major	oligopeptidase b	0.0067	0.1254	0.3271
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.01	0.2091	0.5478
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0054	0.0923	0.2419
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0072	0.1387	0.3635
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0088	0.1783	0.4671
Echinococcus multilocularis	acylamino acid releasing enzyme	0.0018	0.0008	0.0021
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0065	0.1212	0.3175
Brugia malayi	Proteasome A-type and B-type family protein	0.0075	0.1446	0.3787
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0075	0.1446	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0072	0.1387	0.3635
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0043	0.0113
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.1083	0.2837
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0075	0.1446	0.3787
Brugia malayi	Protein kinase domain containing protein	0.0069	0.1293	0.3388
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.1083	0.2837
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0072	0.1387	0.3635
Trypanosoma cruzi	oligopeptidase b	0.0067	0.1254	0.3271
Echinococcus granulosus	tyrosine protein kinase HCK	0.0058	0.1032	0.2703
Schistosoma mansoni	tyrosine kinase	0.0054	0.0919	0.0919
Schistosoma mansoni	hypothetical protein	0.0019	0.0043	0.0043
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0075	0.1446	0.2134
Trypanosoma brucei	oligopeptidase b	0.0067	0.1254	0.3271
Mycobacterium ulcerans	proteasome PrcB	0.0075	0.1446	1
Mycobacterium ulcerans	protease II (oligopeptidase B), PtrB	0.0067	0.1254	0.633
Brugia malayi	Protein kinase domain containing protein	0.0122	0.2651	0.6945
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0018	0.0008	0.0021
Echinococcus granulosus	carboxylesterase 5A	0.0054	0.0933	0.2445
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0075	0.1446	0.3774
Loa Loa (eye worm)	carboxylesterase	0.0054	0.0933	0.2445
Echinococcus multilocularis	epidermal growth factor receptor	0.0057	0.0994	0.2605
Brugia malayi	SRC-1	0.0072	0.1387	0.3635
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0072	0.1387	0.3635
Schistosoma mansoni	tyrosine kinase	0.0057	0.0994	0.0994
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0168	0.3817	0.3817
Echinococcus multilocularis	epidermal growth factor receptor	0.0057	0.0994	0.2605
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0067	0.1254	0.3271
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0072	0.1387	0.3635
Loa Loa (eye worm)	hypothetical protein	0.006	0.1083	0.2837
Brugia malayi	Cytochrome P450 family protein	0.0043	0.0646	0.1693
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0088	0.1783	0.4671
Trypanosoma brucei	prolyl endopeptidase	0.0168	0.3817	1
Brugia malayi	prolyl oligopeptidase family protein	0.0018	0.0008	0.0021
Loa Loa (eye worm)	SRC-1	0.0072	0.1387	0.3635
Schistosoma mansoni	tyrosine kinase	0.0054	0.0919	0.0919
Loa Loa (eye worm)	cytochrome P450 family protein	0.0043	0.0646	0.1693
Loa Loa (eye worm)	acetylcholinesterase 1	0.0054	0.0933	0.2445
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0072	0.1387	0.3635
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0075	0.1446	0.1446
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.01	0.2091	0.5469
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0958	0.0958
Brugia malayi	prolyl oligopeptidase family protein	0.0168	0.3817	1
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0018	0.0008	0.0021
Entamoeba histolytica	protein kinase, putative	0.0058	0.1032	0.7121
Brugia malayi	prolyl oligopeptidase family protein	0.0018	0.0008	0.0021
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0043	0.0113
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0072	0.1387	0.3635
Echinococcus granulosus	GPCR family 2	0.0019	0.0043	0.0113
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0168	0.3817	1
Echinococcus granulosus	acetylcholinesterase	0.0054	0.0933	0.2445
Loa Loa (eye worm)	hypothetical protein	0.0168	0.3817	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.1083	0.2837
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0602	0.1576
Echinococcus multilocularis	insulin receptor	0.0122	0.2651	0.6945
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0043	0.0113
Loa Loa (eye worm)	hypothetical protein	0.01	0.2091	0.5478
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0072	0.1387	0.3635
Brugia malayi	Carboxylesterase family protein	0.0054	0.0933	0.2445
Plasmodium falciparum	proteasome subunit beta type-5	0.0075	0.1446	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0072	0.1387	0.3635
Schistosoma mansoni	tyrosine kinase	0.0057	0.0994	0.0994
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0043	0.0113
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0168	0.3817	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0065	0.1212	0.3175
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.01	0.2091	0.5478
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0958	0.2509
Brugia malayi	Carboxylesterase family protein	0.0054	0.0933	0.2445
Loa Loa (eye worm)	TK protein kinase	0.0058	0.1032	0.2703
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0072	0.1387	0.3635
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1218	0.3191
Mycobacterium tuberculosis	Probable peptidase	0.0067	0.1254	0.1351
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0072	0.1387	0.3635
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0062	0.1137	0.2978
Loa Loa (eye worm)	prolyl oligopeptidase	0.0018	0.0008	0.0021
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0075	0.1446	1
Echinococcus multilocularis	acetylcholinesterase	0.0054	0.0933	0.2445
Toxoplasma gondii	prolyl endopeptidase	0.0168	0.3817	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0602	0.1576
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0075	0.1446	1
Toxoplasma gondii	proteasome subunit beta type, putative	0.0075	0.1446	0.3774
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.01	0.2091	1
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0067	0.1254	0.3271
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0018	0.0008	0.0021
Schistosoma mansoni	hypothetical protein	0.0019	0.0043	0.0043
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	0.0151	0.3371	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0065	0.1212	0.3175
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0018	0.0008	0.0021
Schistosoma mansoni	hypothetical protein	0.0019	0.0043	0.0043
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0958	0.0958
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0018	0.0008	0.0008
Schistosoma mansoni	hypothetical protein	0.0041	0.0602	0.0602
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0018	0.0008	0.0008
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0075	0.1446	0.3787
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0067	0.1254	0.3271
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0958	0.2509
Echinococcus multilocularis	carboxylesterase 5A	0.0054	0.0933	0.2445
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0067	0.1254	0.3271
Schistosoma mansoni	tyrosine kinase	0.0057	0.0994	0.0994
Schistosoma mansoni	tyrosine kinase	0.0054	0.0919	0.0919
Schistosoma mansoni	tyrosine kinase	0.0122	0.2651	0.2651
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0054	0.0923	0.2419
Brugia malayi	prolyl oligopeptidase family protein	0.0018	0.0008	0.0021
Schistosoma mansoni	tyrosine kinase	0.0072	0.1387	0.1387
Brugia malayi	prolyl oligopeptidase family protein	0.0018	0.0008	0.0021
Echinococcus granulosus	epidermal growth factor receptor	0.0057	0.0994	0.2605

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.122 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	6.3096 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	17.7828 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1906177

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1551117